A
Abaddon is the demon who thinks that she is queen
Alistar is Dean's torturer
Azazel is the demon with yellow eyes that cursed Sammy and burned their mother
Anna Milton is the angel that lost he grace and tried killing john and Mary
Ash is the one who was the computer tech
Adam Milligan still in hell, with Lucifer
Alpha Vampire the one that controls all the vampires
Amy Pond Sam's first crush
B
Bobby Singer is like a father to Sam and Dean
Balthazar is the dashing one who always gets himself into trouble
Bartholomew a new leader of the fallen angels
Ben Braeden is deans thought to be son
Becky Rosen is the crazy fan girl obsessed with Sam Winchester
Bela Talbot is the sneaky one going behind backs and swiping things
Benny Lafitte is Dean's vampire friend from purgatory
C
Castiel is the angel of the lord that came to earth and helped the Winchesters
Cain was the brother of Abel and is a retired demon known as the Father of Murder who used to train the Knights of Hell, as he is the first Knight of Hell.
Christian Campbell was a hunter, and a third cousin of Mary Winchester. He later became possessed by a demon.
Crossroad Demons are the ones you sell your soul for.
Crowley the king of hell and thinks he is friends with the Winchesters
Charlene "Charlie" Bradbury is a hacker-turned-hunter. She helped Sam and Dean find out what Dick Roman was searching for.
Chuck Shurley a profit that wrote the supernatural books and then disappeared.
Chet was a leviathan who has taken the form of a credit card company employee.
D
Dean Winchester is a human and hunter, formerly a demon, a member of the Men of Letters with his brother Sam and one of the lead protagonists, also a temporary antagonist, in Supernatural. Dean is best friends with the angel Castiel, close friends with the late prophet Kevin Tran and reluctant ally of Crowley
Death is the eldest and most powerful horseman of the apocalypse. He is so old, he cannot remember when he came into being, and says it is possible that he could be as old, or even older than God Himself.
Richard "Dick" Roman was a billionaire businessman and the secret leader of the Leviathans, having murdered the real Dick Roman shortly after they were unknowingly released by Castiel.