Blossom, Bubbles and Buttercup, collectively known as the Powerpuff Girls, were not your ordinary, everyday little girls. These girls had superpowers, which they used to fight crime and the forces of evil. One run-in with three super-powered boys, however, would change all of that.

The girls were at home, enjoying the weekend. Blossom was out jumping rope, Bubbles was playing with her favorite stuffed animal (a purple octopus named Octi), and Buttercup, ever the tomboy, was playing Mario Kart Wii. They had no idea that their lives were about to be turned upside down and inside out.

Suddenly, Professor Utonium, their creator, came rushing in. "Girls, girls! Come look what I made!" he cried. They followed him down to his lab, where a very tall object stood covered by a cloth. He pulled off the cloth, declaring, "I present to you my latest invention! It's a machine that emits a ray. Whoever gets hit by the ray instantly becomes a teenager!" The girls were quick to agree to be careful around it. They had no idea, however, just how hard this would be.