When he came home the night of attack on the Williamsburg Bridge all bruised and scraped up, she just knew. Her beloved nephew was the person everyone called 'Spider-Man'. The teenage boy she and her belated husband raised since he was six, was going out and saving the world.
When he came home after Doctor Conners had been arrested, limping and with cuts all over his face, she knew that Peter Parker had just saved New York pretty much single-handedly. He had help of the officer who was killed on the roof of the OsCorp building, but he was the one to stop the giant lizard. She wanted to talk to him about it, but when he pulled the eggs out of his backpack, she realized that he wasn't going to talk about it. All he did was put the eggs on the table and embraced her into a hug.
That same night while she was cleaning the cuts on his face, he told her that ever since Ben's death he'd been going out and picking fights with local gang bangers trying to find the one who killed the most important man in both of their lives. She knew that he was trying to find the killer, but he wasn't purposefully picking the fights. He was just stopping them and seeing if it was the murderer. He couldn't hurt anyone, it wasn't in his nature.
When he was late for his own graduation, she knew the he was fighting crime. Later that night when the news was talking about the car chase that had taken place that morning and Spider-Man, she couldn't help but beam with pride that her beloved nephew had stopped the thieves. When a picture of one of the bad guys came on the screen of him webbed in the middle of a road with his pants around his ankles, she couldn't help but laugh.
When she laughed, Peter came in to see what she was laughing at, before laughing along with her. He muttered something about Spider-Man being funny, then left the house to go have dinner with his girlfriend and her family.
When she found the red tape web on his wall a few weeks later, she knew that he looking for answers. What she didn't know, was it for himself or for Spider-Man? When he asked, she tried to talk her way out it, but then he told her that he needed the information. She told him what she knew and left his room, knowing he would fill in the missing pieces.
The day after Gwen's funeral, she found his Spider-Man suit thrown in the back of the closet, she knew that he giving up on being a hero. She knew why too. Gwen had died in his arms after he tried so hard to rescue her. He didn't blame Harry Osborn, the one who really killed her. He blamed himself, because he failed to save the woman he loved with all of his heart.
As days, weeks and months went by, he kept going to see her, while the rest of the New York wondered where their spider-like hero was. Some where saying that he died. Others said he moved. The rest figured he'd given up or was no longer able to protect the city. She needed a way to bring Spider-Man back to life.
One day while the news was talking about Spider-Man's disappearance again, she told him about how putting her deceased husband's stuff in storage made her lighter and better. She merely suggested that he do the same thing with everything that had been weighing him down.
Later that day when the news showed footage of her nephew in his Spider-Man outfit, fighting the metal rhino, she couldn't stop herself from smiling with pride. When he came home that night with scrapes and bruises, she knew that he could never stop being Spider-Man. No matter how hard and turned around his life got, he would also be New York's hero and she would always pretend that she didn't who he was. At least until he was ready to tell her. When he did, she would act like she never knew that he was Spider-Man.