A Shapeshifter and a Werewolf got together and had a child that had both of their traits and that child married a Witch. Their son married a Faerie and over the years they married Faeries that were Royalty in a tribe, years later they had a son named William Thomas Compton or Bill. Since both of his parents were Faerie he became a full-blooded Faerie, and that helped unlock his other abilities. While he was in the woods he encountered a beautiful naked woman, dark as the night, who could move at astonishing speed. Astonished by the smell of his blood, the women named Lilith who told him she was a Vampire and she then asked him if he wanted to be a Vampire and he said yes.
When he couldn't find his Faerie family he decided to travel and meets many Vampires, Werewolves, Shapeshifters, Skinwalkers and Faeries. While he was away Lilith turned the Fae Macklyn Warlow into a vampire in the year 3500 BC, as she was 'told by God' that he would save the vampire race. However, Warlow grew to despise her after he attempted to return home four years later (against her advice), and then proceeded to slaughter his entire village, due to his vampiric instincts. He returned to the cave in which she slept, and used his photokinesis to destroy part of the ceiling of the cave, allowing the sun to come through and destroy the progenitor of all vampires. However, a small amount of her blood remained. Lilith's other progenies gathered her remains in an earthen jar.
When Bill found out that his Maker died at the hands of Macklyn Warlow her Progeny, he decided to find him and kill him. But he couldn't find him because he stayed away from Vampires. In April 9, 1835 he meet a human female by the name of Caroline Shelby who was born to Stewart and Claire Shelby, and moved to Bon Temps in around 1855. Coming from an upper-class Southern family. They got married and had a son Thomas and a daughter Sarah. When the Civil War broke out he went to fight and when he came back Thomas died of small pox.
When Caroline saw his red tears she shoot him, and when he didn't die she tried to flee Bill stopped her and glamour her into thinking he died and to leave with their daughter. He soon meet Lorena Krasiki and they spent years together. In 1905 they settled in San Francisco for a time, and frequently visited the Comstock Brothel run by Pamela Swynford De Beaufort. The pair delighted in torturing and slowly draining the prostitutes there. However, the much older and more powerful vampire Eric Northman.
Pamela or Pam fell in love with him and she wanted to join him but her Maker didn't want her to. So Bill and Eric got into a fight with Bill winning even thou he didn't use his other powers. When Jesse Compton died he got the Compton house back. He, Lorena and Pam decided to move back to Bon Temps to see what happened to his family. There he found out that his granddaughter Elizabeth married James Bellefleur.
They had a son Arthur who married someone and had James Bellefleur who married Caroline and had two sons. One of them had Andy and Portia and the other had Terry Bellefleur. Terry married Ariene and adopted Ariene's three kids Coby, Lisa Fowler and Mikey who is the son of Drew Marshall. He moves into his house with the two Vampires. He decides to not tell the Bellefler they are related.