Part One:

Osmosis Jones walked briskly up the stairs of Cerebellum Hall and headed towards the elevators He arrived at the top and walked toward the mayor's office clutching a file in his hand. Opening the door he looked over to see Leah, the mayor's assistant, hunched over her desk working furiously.

"Leah girl!" He greeted.

Leah looked up and rolled her eyes.

"What do you want Jones?" She asked raising an eyebrow to the cell.

"I came to see my girlfriend!" He replied as she gave a little grin. "And to give the mayor this." He added pointing to the file raised in his other hand.

"What is it?" She asked getting up and walking around her desk.

"It's a report. There's been some strange happenings and I wanted the mayor to know what's going down."

"Well Ozzie….Mr. Colonics out right now, but I'll be happy to get that to him for you."

Ozzie nodded handing her the file. "So…up to anything good baby?" He asked teasingly.

"Nothing that concerns you." She retorted giving him a smile and sitting back behind her desk. "Where's Drix by the way?"

"He's back at the precinct in our office."

"I'm surprised you leave that thing…you really like it don't you."

"Yeah girl! I'm proud of my office."

She looked up at him about to tease him about his office being a mess when his phone rang.

"Wha…?"

She looked at his confused look and shrugged.

"Osmosis Jones here." He answered.

"Jones?" A worried voice answered to him.

"Drips? What's up?"

"Um Ozzie there's a problem. Something's wrong with Frank."

"What is it?" Ozzie asked panic etched his voice.

Leah looked at him with a worried look. Not paying attention to her he ran out of the mayor's office phone pressed to his face.

"OZZIE?" She yelled after him.

Out in the hall he stopped.

"So Drix what's wrong?"

"I don't known but you better get back here fast."

Ozzie hung up and rushed to his car.

Leah stood there and watched him fly out the front door, but as it happened a little black box dropped out of his pocket.

"What's this?" Leah said opening the box. When it was opened it revealed a gold diamond ring. Leah squealed and threw it across the room.

"Oh my gosh!" She exclaimed. "Was he gonna propose?"

She sat back down and rested her forehead on her palm. She flew up from her seat, picked the box up, and placed it on her desk. She paced the room and finally walked back, sat down, and got back to her paperwork.

Meanwhile Ozzie sat in his car honking the horn furiously.

"OH COME ON! I GOTTA GET BACK TO THE PRECINCT." He yelled. "I don't have time for this." He mumbled. He shoved his hand in his pocket and pulled out his phone. He was about to call Drix when there was a break in the traffic. Scooting around a few cars he turned down and headed towards the lymph nodes. He arrived to the precinct and halfway ran towards Drixes and his office.

"Drix…yo what's up? What's going on?"

"I don't know Ozzie."

"Well what did you call for?"

"Something's going on in this body."

"Well…..what info can you give me?" Ozzie asked taking a seat at his desk and looking to Drix.

"Well not much." Drix replied. "Except.."

"What is it?" Ozzie questioned.

"There are some missing sperm cells."

Ozzie blinked. "Ohhhh..ew!"

Drix quivered.

"So what you think? An S.T.D?"

"Maybe." Drix replied.

"Alright, we'll go investigate later..I'm going to dinner with Leah."

"O.k. Bye."

Ozzie drove back to see Leah.

"Uh…hi Ozzie." She said weakly as he walked in.

"Sup."

She slipped the ring back in his pocket without him noticing.

"Ready to go?"

"Ye…yeah."

"You ok?"

"Uhhu."

"Ok, Damn my shoes untied." Ozzie got down on one knee and started tying his shoes. Leah left her and out. Ozzie looked up.

"Could you get your hand out of my face?"

Leah looked stunned.

"Alright vamonos." And they left.

Arriving at a new restaurant Leah stepped out of Ozzie's car. Sighing she walked around the front to meet Ozzie as he slid out of the drivers side.

"You hungry?" He asked looking to her.

"Wha…?" She asked startled.

"I asked if you were hungry."

"Oh yeah I guess."

"Good." He said holding the door for her.

Once they were seated with their menus she sat hiding behind hers.

'What's going on with him?" She wondered. 'What is that damn ring for?"

"So what you havin'?" He asked.

"Oh um..not sure."

"Yeah me either." He put his menu down. "So what's up with you? Your actin' weird."

"No I'm fine. Just been workin hard all day." She replied.

"You sure that's all?"

"Ummhmm." She mumbled nodding.

He shrugged giving her a small smile. She gave him a small grin nback and went to looking back at her menu.

Back at the brain the mayor arrived back at his office.

"Leah?" Tom called. "Are you here?" He walked towards her desk and then further in the office to his own. Picking up a piece of paper he noticed it was a note from his assistant.

"Out to dinner with Ozzie." He mumbled to himself. "At least she's out and safe…most likely."

He sat at his desk pulling a few papers out of a drawer he got to work waiting for his assistant to return.

At the restaurant Ozzie and Leah were finishing their dinner. They both were paying more attention to their food than each other. Ozzie finally stopped eating. He looked to Leah.

"Leah….I've gotta talk to you."

Stunned she looked to him.

"About…what?" She asked. 'This is it! This is the time.'

"Well me and Drix think Frank might have an S.T.D. Have you noticed if he's you know…..?"

"That's all.?"

"Well yeah."

"Oh." She said sighing. "No he hasn't. Not that I know of."

"Ok….well ready to go?" He asked throwing some cars on the table.

"Yeah I guess."

The 2 arrived at the mayor's where they said a short goodbye and he headed to go to the precinct to investigate.

Leah headed up to the office.

"Leah….good to see you! Did you have a good dinner?"

"Yeah……..oh." She grabbed her head suddenly dizzy.

"Leah are you ok?" He asked.

"I…" She was able to choke out before collapsing.

"What the?" He said. He ran out of the office to get some help and noticed a few more brain cells collapsed on the floor. Heading back to his office he called Ozzie and told him to hurry up to his office. He walked back over to his assistant. Sitting on the floor he put her head in his lap and waited for Ozzie and Drix to arrive with help.

Meanwhile back at the office.

"On the way down, I saw you and you saved me from myself. I won't forget the way you…." Drixes belting was interrupted when Ozzie ran in franticly and began to stare.

Drix chuckled.

"Come on, something's up with Leah." Ozzie told as he ran back out the door.

"Right." A moment of silence passed. "I TOOK A DIVE AND…" Drix then went out the door with Ozzie.

While Ozzie and Drix hurried to see Leah, the mayor got a strange shady visitor.

There was a knock on the door.

"Ozzie? Bout time." But when he opened the door it wasn't Ozzie. "Who are you?"

"Oh I'm Hepatitis."

"Hepa…Hepatitis, hepatitis what?"

"I'm Hepatitis B,C and G son!"

The mayor looked baffled.

"Now." Said Hepatitis. "Hang over the bling bling my zing zing."

"ZING ZING."

Just then Ozzie and Drix arrived.

They stepped through to the elevators. Arriving at the top they noticed a few more brain cells sprawled on the floor.

"Yo Drips this is a little more than just an S.T.D. This is affecting Frank's brain."

"Yeah. We better get help for these cells."

"You call..I gotta go find Leah."

Drix nodded and went to a phone to call for the F.P.D. Ozzie continued to the mayor's office where he found the mayor stuck at his desk by a freakish looking virus and Leah on the floor. Running over he picked up her head off the floor.

"Leah…girl…come on wake up."

"JONES! You're here." The mayor called.

"Yeah me and Drix just got here." He said placing Leah's head on the floor again. "So who's the um..visitor?" He asked walking over to the mayor's desk.

"I'm Hepatitis…and you are?"

"Osmosis Jones…FPD." He said flashing his badge.

"You called a cop on me?" Hepatitis yelled grabbing the mayor around the neck.

"No…honest…that's his girlfriend over there. I called him because she passed out!."

"Hmmm…Well Jones come here behind his desk. I don't trust you."

Ozzie walked around and stood next to the mayor. Hepatitis walked towards Leah pulling out a plasma gun.

"I think we need to be rid of the lil miss."

Just as he was about to shoot her Drix came in and froze his gun. Ozzie breathed a sigh of relief.

"Thanks Drips."

"What the fizzle my nizzle?"

"You just got got." Ozzie said taking out his handcuffs.

Drix smiled and put on his head phones. "On the way down…"

Just then Hepatitis broke free of his ice prison and made a break for the door.

"Drix get him!" Ozzie yelled, but Drix's loud music and closed eyes allowed Hepatitis to escape.

"Yo. YO! DRIX!" Ozzie yelled. He walked angrily over to Drix and yanked the headphones off. "Drix you just let Hepatitis free. Now he's runnin loose through Frank's head!"

"I did? Oh goodness."

Ozzie let out a huge sigh. Throwing his hands up he walked over to where the mayor was tending to a still unconscious Leah.

"You ok Mr. Mayor?" He asked kneeling down next to him.

"Oh yes I'm fine thanks. I'm just worried about Leah and all the other brain cells."

"Don't worry Mr. Mayor me and….well at least I will make sure Hepatitis is found and we'll get Frank back to normal."

"Jones..I'm no Immunity Cell but I think this may be more than Hepatitis."

"Yeah me too." Ozzie said as he stood up grabbed the file from Leah's desk and handed it to him. "This is some info I found myself." He continued.

The mayor nodded as he grabbed the file from Ozzie's hand.

"Well me and Drix better get going." He said finally. He grabbed a few files and things off Leah's desk and propped her head up on it. "If she waked up please call me." Ozzie added getting up and walking over to his partner. "Come on ." He said angrily as he grabbed Drix's arm and pulled him out.

The mayor watched as the 2 left. Looking back to Leah he knew something was way wrong with Frank….

While driving in the car on the way home Ozzie went off on Drix.

"You stupid mother f. How could you be listening to that Ryan Cabrera fool while we were loaded in a battle with Hepatitis."

"You always put me down." Drix pleated as he started crying.

Ozzie raised and eyebrow and started staring. "I'm uh….sorry." He chanted strangely.

"Its ok." He said as he stopped weeping.

Just then Hepatitis jumped on their windshield while Ozzie was still starring. "Gothcniger"

"Holy Spit." Ozzie yelled swerving his car. Coming to a stop Hepatitis jumped off and made a run for it. Ozzi got his gun out and went after him. "Guard the car Drix!." He yelled over his shoulder.

Drix pouted in the car saddened by the fact that he couldn't join the chase.

Back at the Mayor's:

The mayor sat worried next to Leah who had still not woken up. 'Help was supposedly on the way.' He thought. Just then a few of the Frank Medical Cells came in.

"This her?" One asked.

The mayor nodded and a few cells came over and gingerly picked up Leah and carried her out to awaiting cars.

Back to the chase:

Ozzie had been running for 5 minutes or so and Hepatitis was nowhere to be found.

"Dang where'd he get to?" He mumbled to himself. Just as he turned his back he was tackled to the ground. His gun fell just from his reach. "Who the?" He sputtered out. He winced in pain as his badge stabbed into his chest a bit.

"You been following me for quite sometime Jones."

"Hepatitis!"

"Hmm very good. You're a smart one aren't you?" Hepatitis sneered angrily.

"Look dude..I'm gettin you outta Frank..nothin else will infect this body when I'm around." Ozzie hissed from his position.

"Well Jones…that was a dumb thing to say, especially since it seems I'm the one who's got you." Hepatitis replied slightly twisting Ozzie's arm behind his back. "Soon the FPD wont have its finest cop….and your little girlfriend will be mine."

"Leave Leah outa this buddy…she has nothing to do with it.."

"Oh but I think she does…."

Ozzie secretly used his beeper to get Drix.

Back at the car:

Drix sat with his arms crossed very "pissed". He turned the radio on and it was his favorite song.

"On the way down.."

With the blaring music Drix wasn't able to notice the beeper.

Back to Ozzie/Hepatitis:

"What do you mean?" Questioned Ozzie caught in a mix of pain and furry.

"Well she's a lovely lady."

"Stop it, don't say that."

"What does it bother you?" Hepatitis said with a smile.

Ozzie was silent but he kept on beeping Drix.

Back to the car:

"Awwww it's over." Drix said very depressed. Then he heard his beeper. "Oh crap. Ozzie's gonna be mad." He jumped out of the car and went to go find Ozzie.

Back to Ozzie/Hepatitis:

"Well Osmosis it looks like you met your match." Hepatitis was just about ready to kill him when finally Drix arrived.

"Stop right there Hepatitis." Drix said sounding as tough as he could and aiming his arm at the germ.

Hepatitis put more pressure down on Osmosis who was still stomach down on the floor. Ozzie let out a small whimper as his badge dug more into his chest.

"You shoot me and I shoot your little partner here." Hepatitis said grinning.

"Let Ozzie go." Drix said.

"I don't think I want to."

"Let him up Hepatitis. Holding a cop hostage like this makes your situation even worse!"

"Yeah well he's your partner so that makes your situation worse as well. You know….I could dispose of both of you right now and use that lovely girl of yours to take over Frank."

"Leave…Leah…alone." Ozzie said through grinted teeth.

"Yes Hepatitis…Leah has nothing to do with this so leave her out of it." Drix said.

"Hmmmm…yeah sure….She'll make a great assistant to me."

Drix wasn't sure what to do, the conversation had dies and now there was an eerie silence.

"Let him go." Drix repeated. Hepatitis shook his head.

No one ould see to make up their mind on what to do. Finally Hepatitis used his quickness to swiftly hold down Ozzie with one hand and fired a shot at Drix. It missed badly but hitting Drix wasn't Hepatitis' intention, for it distracted Drix, giving Hepatitis enough time to get away with Osmosis.

"What the? OZZIE!" Drix yelled. 'What do I do?' He thought panicking. "What is he gonna do to Ozzie?" He was so panicked he couldn't think straightly. Finally making up his mind he hurried back to the car. "This is going to be difficult seeing as how I have no legs." He muttered starting the car and heading back to the precinct.

At the medical center:

The mayor paced the "waiting room" hoping to hear news about his assistant. A doctor finally walked into the room looking upset.

"Mr. Colonic?" He muttered.

"Yes!"

"Well she's still unconscious and has worsened but it seems she's fighting to live."

"Well that's good…at least she's….fighting."

"Yeah…well…..I better check the rest of the cells."

"Ok." Tom muttered sitting in a nearby chair. Pulling out his phone he called Ozzie. Not getting a reply he called Drix.

"Hello?" Drix answered as he made a screeching halt at the precinct.

"Drix….where's Jones?"

"He was….kidnapped sir…why?"

"Kidnapped? One of our best officers was taken?"

"Yes sir….I'll find him thought."

"Well…I'll tell you then. Leah…she's gotten worse but the doctor said she seems to really be fighting to live."

"That's good."

"Yeah." The mayor choked out on the verge of tears. "Well I'll let you go. I guess."

"Ok."

"And Drix?"

"Yeah?"

"Bring Jones back safely."

After a small pause Drix replied "Ok." And hung up.

The mayor, who had stood up in the middle of the conversation, plopped back down in a chair and buried his face in his hands.

Back with Drix:

Drix 'walked' down the hallway and paused in front of the chief's door. Slowly he headed in.

"Chief?"

"What do you want?" The chief asked grumpily.

"I'm not sure how to tell you this but….Jones was kidnapped in a way. Hes being held by Hepatitis."

The chief's face softened, his mouth falling open.

"Jones?" He repeated. "You know I always give him a hard time but…he's a god cop..even though he thinks he's the only cop out there."

"He's a good partner." Drix added.

The chief nodded looking quite sad.

"Well I'm gonna start working on finding him." Drix said before turning to leave the office.

"Hey Drix….if you need help…just let me know."

Drix gave a small nod of his head and went to the office he shared with his missing partner. He went over to his desk and prepared for a long night.

Bar:

Drix sat there feeling quite depressed about the whole situation. He tried to drink his sorrows away, even the fact that his favorite song was on didn't cheer him up.

"On the way down I saw you and you saved me from myself…"

Drix sighed. "I wish I knew where Ozzie was."

"Down." Ryan Cabrera sang over the radio.

"I mean, where could they be?"

"Down, Down, Down."

"Maybe they…."

"Down, Down, Down."

"Maybe they went down!"

The song went on…

"They went somewhere down in Frank near the bottom, I know it!" And with that Drix and his drunk self ran out in pursuit of Ozzie.

With Ozzie:

Ozzie let out a small whimper as he was thrown against a wall in, what he assumed was, the lower leg. Falling to the floor he let out a small cry in pain. His jacket had been discarded and he gave a small shudder. Sure he had been beaten up by viruses before but never like this. Badly bruised he curled up hoping Hepatitis would leave him alone.

'I wish Drix or Leah was here.' He thought to himself. 'I hope Leah's ok…hopefully they got her help."

Finally he was so tired and in so much pain that he fell asleep. Hepatitis came back in a noticed the cell curled in a ball and asleep. He grinned. He watched as Ozzie shuddered every once in a while when he was breathing. Knowing he had put the cell through so much he smiled. Finally an idea popped in his head.

'If I can kidnap that girl of his and torture him even worse it will be ideal!' He went to work on his plan leaving the beaten cell to sleep.

Back to the Mayor:

"Mr. Colonic….Mr. Colonic?" The doctor asked nudging the Brain Cell awake.

"Yeah?"

"Your assistant seems to have woken up. You can go see her."

"Thank you so much." He said as he ran down the hall to her room.

"Mr. Colonic!" Leah greeted.

"Hey Leah. How do you feel?"

"I'm good…Where's Ozzie?"

"Umm…I have something to tell you."

"What? What's wrong?"

"Ozzie was….well he was taken hostage by Hepatitis."

"No…It, it can't be." She yelled breaking down.

He walked closer to his assistant and wrapped her in a comforting hug.

"I'm so sorry Leah….But we'll find him I promise. Don't worry."

They stayed like that for a while as she sobbed for Ozzie.

Hepatitis' plan was coming along great. In only a few hours he knew exactly what he wanted to do and was just about ready to do it. But just as he was about to set out a drunk fool stumbled in….no wait it was Drix.

"Ozzie, Ozzie you hurr?" He said very drunk.

Hepatitis chuckled then slapped him.

"Hey you hit me." And with a grunt he punched Hepatitis and sent him to he floor. Hepatitis, now raging with furry, jumped on top of him, punched him 12 times before his CD player fell out and started playing….

"On the way down I saw you and you saved me from myself."

Hepatitis was pissed…

"I hate that goddamn song" Hepatitis then stomped on the CD player but when e stomped on it another song started playing.

"Drop it like it's hot, Drop it like it's hot."

"Hell yizzle this is my jam!" Hepatitis started doing a strange dance.

Meanwhile Drix said dazed when through a small window he saw Ozzie. Noticing that Hepatitis was a little preoccupied with his dancing he snuck past Hepatitis and was able to get Ozzie. But just as Drix and Ozzie were walking out the front door the song ended and Hepatitis started to chase them.

"Drix how did you know I was here?"

"I…uh…no clue.."

"Drips Yo, your drunk aren't you?" Ozzie interrogated as they ran towards Ozzie's car.

"Maybe a little.." Drix replied.

"Yo your totally smashed."

"No….yes…maybe."

Ozzie jumped in the drivers seat and Drix stumbled into the passengers side.

"Oh yeah Ozzie."

"What?" Ozzie asked impatiently as he sped off.

"Leah….she's gotten worse last time I heard."

Ozzie's face grew solemn and he starred ahead.

"Oh." He replied shortly. He turned and headed towards the medical hospital.

"Ozzie what the?"

"I'm going to see Leah."

They arrived and headed up to Leah's room. She was sitting up in her bed when he walked in.

"Leah girl! Your ok!" He said happily.

Leah looked up . She reached out and he wrapped her in a comforting hug.

"I though I lost you Ozzie!" She muttered into his ear.

"Not yet." He replied.

Suddenly there was and explosion from a near by building. Ozzie looked out the window to find a huge mofo looking gun.

"Ozzie come out to play." Hepatitis yelled.

"Don't!" Leah told Ozzie quickly.

"I have to." He told her. She began to shed a tear and with that Ozzie left.

He walked outside to greet Hepatitis and it looked as though the big Osmosis Jones- Hepatitis B battle would finally begin…then Drix passed out.