Years in the future, the now-adult Powerpuff women were still fighting crime and saving the day.
Bubbles has taken a job as the teacher at the Pokey Oaks Kindergarten after Ms. Keane retired. She loves teaching her students and is loved by them in turn.
Blossom helps out at city hall, assisting Mayor Bellum after the old mayor retired, servings as the team's primary liaison with the city's government.
Buttercup joined the Townsville police department and is currently the sister most involved in fighting crime.
All three women still live at home with their dad, Professor Utonium.
But what of the villains, you ask?
The genius chimp, Mojo Jojo, spends his days, up in his volcano lair, kicking himself for throwing away the chance he had when he took over the world, when he's not hatching the occasional scheme against the Powerpuffs to stave off boredom.
Him has been quiet for some years, but the Powerpuffs know to be alert for when he comes out from the shadows to strike.
Fuzzy Lumpkins keeps to himself, as usual, spending his days playing his banjo.
The Gangreen Gang are now one minor street gang among several in Townsville.
Princess Morbucks inherited her family's fortune and companies after her father passed away. Although she claims to have retired from super-villainy, the Powerpuffs still keep a suspicious eye on her activities.
The Amoeba Boys are barely a beap on the Powerpuffs' radar these days. So, as usual then.
Sedusa is currently serving time for her latest scheme.
But, for all their rogues, the most dangerous ones are on the loose: the Rowdyruff Boys!
The Powerpuffs' male counterparts, they were created by Mojo Jojo for one purpose: destroying the Powerpuff girls. But nowadays, they have expanded to causing general chaos and terror against the innocent citizens of Townsville.
Brick, the leader, is more professional than his brothers, though not by much. He does show some restraint when shaking down gang leaders for money or information, but when challenged, his ego and vindictiveness shine through.
Butch, the mad dog, is always eager for handing out a beatdown, and woe be to the poor souls around when Brick decides to let him off the chain.
Boomer, the youngest, though more reserved than his brothers, still takes pleasure in being the cause of suffering and chaos throughout the city.
The Rowdyruffs were in a standoff with the Powerpuffs for control of the city. In every battle they faced each other, it was an even match.
But, Brick thought up a way to break the tie: create a new batch of Rowdyruffs and train them to fight the Powerpuffs who, being the goody-goods that they are would go easy on them cause they were kids, allowing him and his brothers to take them down while they were distracted.
But, to do this, he required three things: snips, snails, puppy dog tails, & most importantly, Chemical X.
The first three were easy enough to get ahold of, but they had difficulty finding Chemical X as they had to contact several of the gangs to smuggle the chemical to them.
So, it was they stirred the concoction when, as expected, it exploded.
When the dust settled, they looked upon three five-year old boys who looked just like they did when they were created.
Yet there was something different: unlike the roughness and rage in the originals' eyes, these new ones' only looked at their creators with confusion.