• Jennifer Montgomery Shepherd (21)
• Casey Montgomery Shepherd (17)
• Nicholas Jeffrey Montgomery Shepherd (15)
Mark Sloan and Meredith Grey Sloan• Matthew Derek Grey Sloan (17)
• Scarlette Grey Sloan (15)
• Charlotte Grey Sloan (15)
• Mellissa Cristina Grey Sloan (13)
Owen Hunt and Cristina Yang Hunt
• Caleb Hadith Hunt (17)
• Roxy Delain Hunt (14)
Alex Karev and Izzie Stevens Karev
• Rebekah Paige Karev (16)
• Casadia Lynn Karev (14)
Arizona Robbins and Callie Torres
• Jake Rhys Robbins Torres (17)
• Jordan Ethan Robbins Torres (16)
• Sofia Robbins Torres (15)
Lexie Grey and Carina Deluca
• Daniel Grey Deluca (21)
• Bill Grey Deluca (17)
• Kaiera Grey Deluca (16)
• Alexis Freya Grey Deluca (13)
Jakson Avery and April Kepner Avery
• Ellena Marriot Avery (17)
• Liam Harper Avery (16)
• Crystal Lane Avery (14)
• Kate Rane Avery (13)
Cooper Freedman and Charlotte King Freedman
• Mayson Cole Freedman (23)
• Amber Nicolette Jane King (21)
• Amanda King Freedman (13)
• Caroline King Freedman (13)
• Rachel King Freedman (13)
Atticus Lincoln and Amelia Shepherd Lincoln
• Bryan Shepherd Lincoln (16)
• Eleanor Shepherd Lincoln (15)
• Elizza Shepherd Lincoln (15)
Henry Burton and Teddy Altman Burton
• Helena Meghan Burton (22)
• Harry Tale Burton (17)
• Terrance Dale Burton (15)
• Talia Ann Burton (13)
Ben Warren and Miranda Bailey
• Tucker Bailey Warren (23)
• Zola Bailey Warren (20)
Peter Wilder and Violet Turner Wilder
• Alice Jane Wilder (21)
• Beatrix Leslie Wilder (17)
• Felicity Thea Wilder (17)
• Valentina Penelope Wilder (15)
John Dougles and Nancy Shepherd Dougles
• Elijah Michael Douglas (26)
• Corry James Douglas (25)
• Jonathan Rylie Dougles (23)
• Seriena Vanessa Douglas (17)
Charles Marlou and Kathleen Shepherd Marlou
• Carlton Sanders Marlou (25)
• Arthur Dean Marlou (23)
• Samuel Luther Marlou (23)
• Nathaniel Archer Marlou (19)
Isabella Starlight Shepherd Grey (25) parents are Thatcher (Meredith and Lexie's dad) and Caroline (Kathleen, Nancy, Derek, and Amelia's mom). Issabela is dating Lucas Joseph Kingston (27)