Leslie Willis didn't want to be Leslie Willis anymore. She was tired, so, so, so, tired of being pushed around by Cat Grant, her fairly abusive boss. "Leslie do this, Leslie do that, Leslie you can't hate Superman on national radio, Leslie blah blah blah blah blah!" Honestly, the pay wasn't even good enough to be treated like an indentured servant. I mean, yeah, she got thirty dollars an hour to talk and play music, but still. Leslie wanted to... she didn't really know what she wanted, accept to be out of the skin she lived her emotionally scared life in.
Cisco Ramon didn't want to be "Dante's brother" anymore. "Oh look, there's Dante's brother, what's his name again?" Cisco, it was Cisco Ramon, but in reality, no one actually have a crap, and the worst thing was he knew that. Also, for the cherry on top, Caitlin had moved to Metropolis with Ronnie, and Harrison Wells -who turned out to be super evil- killed his best friend, Barry. He killed The Flash, and then Wells left to go back to his real "home." Wells just left, poof poof, gone.
In retrospect, they were both friendless and going through issues. Issues that just made them want to hide under a blanket, watch Netflix, and eat Mint-Chocolate-Chip ice cream.