Title: Never Say Never

Author: Nikki (Randomness0612/Randomer06)

Rating: M (16+)

Pairings: mainly Alex/Izzie (lexzie) with possible other pairings and characters.

Premise: Meredith, George and Izzie all grew up in Seattle with each other until Meredith moves to Massachusetts with her mom. How will the group stay in touch when they reach college when e-mails and letters become old-school? Who will they meet along the way?

Warning: AU. College/Med School. May become more mature later, unsure at the moment.

Author's Note: Enjoy! =D. This fic is my baby XD

Chapter 1

Izzie Stevens and George O'Malley sat in a biology class at college in Seattle, Izzie barely focusing on the topic being taught to her. She had other things on her mind. Lately Izzie Stevens had drifted apart from her best friend, Meredith.

Meredith, George and Izzie had all grown up in Seattle. They went to the same day-care, same elementary school until Meredith's mom and dad broke up over an affair and she was forced to move to Massachusetts. Izzie tried to keep in touch with Meredith whether it was by phone, letter or e-mail.

At the moment, the only person Izzie had to talk to was George. She needed someone else to talk to other than George. She was lonely. She hadn't had a boyfriend in about a year and just needed to speak to her best friend.

"What's up?" George asked his friend.

"I'm just thinking about Meredith. I just really want to talk to her."

"Well, you set up an instant messenger account when we were in high-school, right?"

"Yeah... You're point being?" She asked, confused.

"You can be really blonde sometimes you know..."

"Just explain." She snapped.

"Get Meredith's messenger name and talk to her on that."

"George, you're a genius. I could kiss you, but I'm not going to. It wouldn't be right."

"Good. I don't think I'd be able to handle it." He answered, causing them both to laugh.

"Plus you wouldn't. Remember when I was desperate for... well, you know, and I asked you..."

"And I replied by saying I would never do you?"

"Yeah, that. And that rule still applies. That rule applies forever."

"What, because I'm your sister" She winked.

"I'm not your sister!"

"Woah, chill George. Just because I asked you to go shopping for girl products one time doesn't mean I'm going to make you again, unless you want to..."

"Nope." The bell rang. "Now I'm leaving."

"Whatever, George. You'll be back!" She shouted after him, laughing at him fleeing.

After leaving college later that day, Izzie arrived home about 5pm, after finishing college and driving back to the apartment she was renting in Seattle. She had moved out of the trailer she had once lived in with her mother. She couldn't stand the thought of her mom bringing back guys to the trailer and not caring about Izzie hearing as Izzie was old enough to understand and take part in such activities.

Izzie opened the front door, which stuck ever so slightly meaning Izzie would have to force it open. She closed the door behind her and placed the bag she'd been carrying all day on floor before taking off her shoes and walking into her living room where her laptop was, placed in the centre of the coffee table, in front of the TV. Izzie reached for the remote for the TV and switched it on as a background feature whilst she tried to add Meredith to her instant messenger.

Izzie sent an e-mail to Meredith asking for her instant messenger identity. The e-mail was replied to within the next half an hour, whilst Izzie made herself some dinner and managed to eat it. Izzie returned to the laptop to find that Meredith had indeed got an instant messenger identity. Izzie added the identity into her instant messenger. Meredith's name then immediately popped up saying she was signed in. Izzie then began to type in the conversation window.

Izzie: Hey :)

Mer: Hey!

Izzie: How are you?

Mer: I'm good. How about you?

Izzie: Lonely. Lol.

Mer: Lonely? You have George. And I bet you have a boyfriend, someone as pretty as you.

Izzie: Nope. I'm single. Have been for about a year. Yeah, I have George but I only have George. Anyway, how about your love life?

Mer: I'm actually dating this guy named Derek. He's a Neurosurgeon. He's based in New York. He's been married but is now separated.

Izzie: Wow. Go you! Met any other cute guys?

Mer: Well, I'm a member of this page .com and some guy named Alex Karev started talking to me. He said we had a common interest and thinks I'm hot. He's hot, but he's not my type. He also added me on facebook. I can send you a link to his page if you want... I'm really good friends with him, have been for about a year now...

Izzie: Yeah, okay. I made a facebook account the other day. George told me I had to.

Mer: Good old George. Tell him to add me on facebook and msn. I'll add you as a friend on facebook and send you the link now. You should also make an account of the other website. You'll meet people who want to be surgeons, just like us.

Izzie: Thanks Mer.

Mer: No problem ; ) Here's the link .69/

Izzie: I just, I need to find someone...

Mer: You'll find someone. Promise. I'll set you up with someone. Look, I have to go now. Derek's taking me on a date. Take a look at Alex and let me know what you think. I'll be on tomorrow. Love ya.

Izzie: Bye! Have a good time! Don't do anything I wouldn't do.

Mer: And that would be... do everything?

Izzie: Shut up and go. Bye. xxx

Mer: See ya. Xxx

A window popped up to say Meredith was now offline. Izzie decided to take a look at this Alex Karev. She clicked on the link.

"Oh, how original. Alex Karev 69. He sounds like a douche already." She muttered to herself.

The window opened and a picture of Alex came up on her computer screen.

"Ooh, wow. He is hot. She said, as she saw a photo of his laying on the floor facing the camera with a sexy smirk on his, wearing a tight pair of white jeans and dark jacket.

He looked like an ass but he was a cute one, she thought. Izzie acted on impulse and added him. She looked at the information section of the page. It said he was interested in women, lived in Iowa and was looking for friendship and a relationship. It said he was single, and it also gave his instant messenger identity.

"Right, I'll add him on both. What harm can it do? It's not like he'll be able to find me or anything. Oh, his msn ID is just as imaginative as his facebook ID. Alex_Karev_69. Great. Here goes nothing..."

Izzie added him, signed off her laptop and retired to her bed for the night.

Izzie got in from college around the same time as the previous day. She signed on to her laptop, msn and facebook again, to see if Meredith was online and to see if Alex had accepted. Izzie soon found out that Alex had excepted as he was talking to her on msn.

Alex: Hey, I'm Alex. ;)

Izzie: I'm Isobel, but everyone calls me Izzie.

Alex: That's a hot name. I bet you're hot too. Do you have a picture? Preferably naked.

Izzie: I was right, you're an ass.

Alex: You have a boyfriend?

Izzie: No, I'm single. Have been for about a year. Meredith is trying to set me up now with a guy...

Alex: Wait, you're Meredith's friend Izzie?

Izzie: Yep. She's awesome.

Alex: Dude, I'm sorry. If I'd known I wouldn't have hit on you straight away. Actually, that's a lie.

Izzie: Thanks, I guess.

Alex: Meredith's shown me pictures of you, the ones you've sent her. You're hot. I'd definitely do you.

Izzie: Ugh. Are you always like this?

Alex: Always babe.

Izzie: Ugh. Okay, so tell me about yourself.

Alex: I'm from Iowa, I want to be a surgeon. I started college in September. I've got a wrestling scholarship. I'm into girls. I'm not a virgin, very skilled in the bedroom

Izzie: Oh, I'd never guess you weren't a virgin, seeing as you're very sexy and girls would be dying to sleep with you.

Alex: You can stop with the sarcasm. You'll learn to love me ;) Anyway, I want to be a surgeon. I'm going to apply for Seattle Grace Hospital once I've finished Med School. It's the best teaching hospital around.

Izzie: I'm applying for there too. I also want to be a surgeon. So does my friend, George.

Alex: So does Meredith. She's applying there too, along with her other friend, Cristina.

Izzie: Meet her online too?

Alex: No, they both go to Smith College in Massachusetts. They'll part ways when Meredith goes to Dartmouth and Cristina to Stanford. So we're all going to apply for SGH?

Izzie: Looks like it :)

Alex: We should meet up before, get to know each other.

Izzie: Not in a sexual way.

Alex: No, as friends. If it does end up being sexual though, I won't be complaining.

Izzie: Nice talking to you.

Alex: You too. Night, Iz xx

Izzie: Bye.