In 2018, a detective working for the special ops division of the Los Angeles Police Department was put on a case to apprehend or retire a group of rogue androids, called Nexus Replicants, who escaped to Earth from the Off-World Colonies. Though he managed to retire each of the five rogue Replicants, the mission would haunt him for the rest of his days. Moments after he completed the task, he quit the force without a second thought.

In 2019, the detective, called by the police force as a blade runner, was called out of retirement to exterminate six Replicants who came to Earth in search of seemingly the same reason as the previous rogues. Though the blade runner retired two of the six Replicants, in which two were killed en route to their rendezvous point, one was killed by his own blaster, the other killed by a Replicant he illegally housed, and the other two were arrested to find out answers as to their reason for coming back to the dying planet, it would not be the last he saw of the ones left alive. Afterwards, the blade runner quietly disappeared.

In 2020, the Tyrell Corporation began to fall into bankruptcy after Dr. Eldon Tyrell met an untimely death at the hands of one of his own Replicants just a year before. Because of this unfortunate turn of events, the United Nations saw fit to dissolve what was left of the corporation by urging it to merge with Weyland, but the combination of the two robotics companies was doomed to fail when the quality of human-like Replicants dramatically decreased without the blueprints of their creator.

In 2021, a blackout all across the Eastern Seaboard plunges half of the populated United States into darkness, for possibly various but unknown reasons, forcing the intensively growing human population into two years of having to defend themselves. Because of their utter dependence on technology to survive and having none of the sort, cities began to collapse and fall into disrepair as the people picked them dry of the last resources.

In 2023, food reserves from Tyrell begin to run low for the United States and the United Nations is forced to call upon a conglomerate synthetic food distributor, the Syntheus Consortium, to supply food for increasingly starving masses all across the world. Though its method to create the synthetic nourishment is unknown, the people are grateful for its existence.

In 2024, the same blade runner is called one last time to locate and retire a series of suspected Replicants in New York City following the disappearances of tens of thousands of humans every twenty-four hours. On this mission, he is told to take up arms with a police-ordained partner for the job who has clues as to the whereabouts of all of the Replicants, but finds himself embroiled in a plot that not only puts the life of his partner on the line but his own.

What they hear about is called the crimson room.