After discovering the secrets held in the Spencer mansion, Albert Wesker's betrayal, and the viral outbreak in Raccoon city, Chris Redfield and the rest of the S.T.A.R.S. team retreated to Europe where the main Umbrella headquarters was rumored to be.

About 10 days later, Claire Redfield came to Raccoon city to search for Chris, only to find that the city had been infested with the living dead. After surviving Raccoon, Claire went to Europe and was captured. She was taken to Rockfort prison where she met Steve Burnside. After escaping Rockfort, Claire and Chris were finally reunited. They destoryed the Ashford twins and escaped Umbrella's Antarctic base just as the base was about to blow.

However...

Little did any of them know that the Spencer mansion, Wesker's betrayal, Raccoon City, Chief Irons, the viruses, the monsters, Rockfort, the twins, Steve's death, and the Antarctic base were all just the tip of the iceberg.

The whole ordeal was merely a prelude of things to come...