This is from 1x07 when Michael saves Sara from the riot in Fox River.
Sitting in the air vents, Michael waited for Sara to collect herself after what was definitely a traumatic experience. It's not everyday you get attacked by a group of crazed convicts in a prison. Michael watched her breathe deeply, trying hard not to break down in front of him. He wanted so badly to wrap his arms around her, reassure her that everything was going to be okay, that he would protect her. But he didn't want to scare her, she was his doctor and he was an inmate. He shouldn't even be feeling this way, not if he wanted to ensure his plan wouldn't fail. He had to remain objective. However, seeing her in this state, Michael couldn't help but feel a pang of sadness and anger at the inmates and he was overcome with the need to make her feel better. So he did what he thought would help; he tried to distract her.
"Ever been to Baja?" At Sara's confused expression, Michael added "Mexico?" She continued to stare at him, not quite able to grasp his words in her current state. Her mind was far too panicked to make small talk. But Michael continued, unfazed. "There is this great place down there. Twenty bucks a night. Hammock on the back deck, beers are 50 cents. 25 cents at happy hour."
Sara smiled, understanding slowly creeping into her face.
"Ever been to Thailand? Thailand's great!" Michael said, enthusiastically.
"Michael," she finally spoke, a smile playing across her lips. "If you're trying to calm me down, you're doing a terrible job."
Michael smiled back, responding with "But I am trying." At this Sara laughed and, just like that, she knew everything was going to be okay. It sounds crazy, she was in an air vent with an inmate, laughing, while several prisoners were trying to find her and do terrible things to her.
She didn't know what it was about Michael - the calming voice, the clear blue eyes, his reassuring smile - something about him made her feel safe. She trusted him, in a place where she knew that trust didn't exist. She had even told him that first day that trust meant very little within the prison walls, yet here she was, putting her life in his hands...not that she'd really had a choice. It was either take his hand or wait for the other inmates to get into her office and she knew the odds were not tipped in her favour. So here she was, following him through the ventilation system, hoping that he'd lead her to safety.
"Ready to go?" Michael asked, holding his hand out to her. Sara looked at his hand for a moment before taking it and, with a reassuring squeeze, he led her further through the vents to safety.