When she was born, her parents died, it was a freak accident to be honest, followed by two events happening that changed the course of the Shinobi world, the first event being that she was taken in by a Legendary figure.
"Tsunade she's your goddaughter, you have to take responsibility for her" a voice said and baby Sakura perked her ears up, it was the first voice she'd ever heard even as she lay crying in her crib not understanding what was going on in the least.
She could only see fuzzy things right now as another voice piped in "I know she's my goddaughter, Mebuki was my best friend after all, but I don't know if I can, you know people always die on me, who's to say Sakura won't as well" another voice snapped.
Voice thick with emotion "Sakura needs to be protected Tsunade, her last name might be Haruno, but we know that she has Senju and Uchiha blood in her, possibly even Uzumaki due to her parents ancestry, and once people learn that her Father was the Fourth she'll be in constant danger" the previous voice snapped back.
For a few minutes there was utter silence all the while baby Sakura cried "Fine I'll take her but don't expect her to come back to this village, once I leave, we stay gone for good" the second voice finally relented to the demands being made of her.
And a fuzzy face leaned over baby Sakura taking her into their arms, rocking her and making shushing noises that had her tears abating, before to long her eyes drooped in tiredness and eventually fluttered shut drifting off into a peaceful sleep.
As for the second event, two powerful historical figures were reborn, their memories in tact and a second chance at life to redo everything, not brothers this time sure, though no one would figure this out until many years later when the time was right.
That very same night that baby Sakura was born, she was taken away from her home "Come Shizune" Tsunade sighed carrying her goddaughter precariously and hoping that she managed to protect the one thing that mattered to her now.
"Of course Milady" young Shizune called following after her dead Uncle's lover as they left the Leaf Village behind where they'd stay away for several years until eventually they were pulled back by a knucklehead blonde with the last name of Uzumaki.
