Big Bang Theory characters in the distant future:

Raj will return to India. He will marry Lalida Gupta to please
his parents. By the time he gets over his social anxiety, he will
be a quart-a-day alcoholic. He will open a successful chain of
addiction rehab centers, become the richest man in India, and
be elected Prime Minister. He will be assassinated on his
second day on the job.

Bernadette will become head of the FDA, even though she is
unsuccessful in her attempt to cure premature ejaculation.

Wolowitz will invent a female sex robot that "is better than
doing it with a woman," acccording to his infomercial. He will
make a billion dollars, but the robots won't have sex with him
either.

Leonard will marry Lesley Winkle, after Penny refuses his 20th
marriage proposal. Lesley will win 3 Nobel Prizes. Leonard
will get a job as docent at her wing at the National Science
Museum. They will only have sex once a year. In spite of this,
they will produce four children. Their 9 year-old will invent
Time Travel.

Penny will marry Sheldon on the rebound. After the wedding,
she will balloon up to 300 lbs. They will live in the same two
fourth floor apartments for the rest of their lives. Sheldon will
ban her from his apartment on the wedding night. He won't go
into hers because she is such a slob. They will never consumate
their marriage.

Penny will have one child, fathered by a Jehovah's Witness who
knocks on her door one day. She doesn't get his name.
Sheldon's mother will believe the Jehovah's Witness was Jesus,
"come down to cleanse Penny's Tarnished Soul." She will
always refer to her grandchild as "the little Savior." Penny will
name the child "Leonardo." She will explain this was for
DiCaprio, NOT Hofstadter.

Sheldon will win the Nobel Prize for discovering and traveling
to a 17th dimension. But they revoke it when he comes back.

After Penny marries Sheldon, Amy Farrah-Fowler will buy one
of Wolowitz's robots, and explore her lesbian urges. She will
abandon her adademic career, and ride with the Lady Pagans.