A young mouse crept into a secret area underneath an old saloon. This secret area was very dark and hardly provided enough light for anyone to see clearly. As he took his first few steps within the area, the mouse's heart pounded hard in his chest because he could hardly see anything in the thick darkness. The young mouse made this journey to the area because the mouse believed that the cause of a lot of recent happenings would be discovered there. The young mouse heard about very strange occurrences that have recently happened in his home town. These occurrences involved mice, mostly male adult mice, which all had picked up a condition where they looked as though as they were very tired or drained of energy.

The young mouse who is searching though the secret area is one who is no stranger to dealing with such cases where his fellow mice are harmed. For, he has dealt with the likes of enemies such as the Cossack cats; the Mott Street Maulers; evil high class mice; a crazy poodle; and lastly the Cactus Cat Gang and their leader, Cat R. Waul. This brave mouse's name is Fievel Mousekewitz. Fievel wanted to find out what causing these occurrences and discover how he could stop them. However, at this moment, in this area, he didn't feel quite so brave because he didn't quite know what he was getting into.

As Fievel walked, he thought back on what he heard about each occurrence. Fievel remembered hearing that each mouse had two small marks on the side of their necks. Also, he heard the mice had showed signs of minor but very noticeable irritability towards sunlight as well. The thought about those holes in the mice's necks made Fievel feel squeamish and it also made his heart pound faster and his breathing heavier as he slowly walked.

On his journey, Fievel then remembered the day he overheard a conversation his mother and father had about what was being said on the street about the doctors' findings over the matter. He heard his papa say that the doctors, who did the diagnoses on the mice, ruled out their findings as a sudden case of something called "anemia". Fievel also heard Papa talk about the sunlight irritability and say that the doctors believed it was a sunlight allergy brought on by the sudden anemia. On the day Fievel heard the conversation, he asked his papa what was "anemia". Papa told him that it was a condition where a person loses a significant amount of blood needed to keep the person healthy. Papa also told Fievel that anemia is usually caused by a disease within the body.

At the time before he went on his journey, Fievel thought about what Papa said about the disease, anemia, and had almost came to the conclusion that these happenings were caused by that disease. However, Fievel remembered that each mouse with that condition had those two marks on their necks. He thought on that fact for a while. "What could have caused those marks?" Fievel said to himself as he went outside that day to take a walk. As Fievel continued to think on the fact, he wasn't watching where he was going and he walked directly into a rose patch. Fievel fell on a rose and accidently pricked his hand on the rose's thorn. He got up and pulled the thorn out of his hand. However, when Fievel looked that his hand, he noticed that the prick as it bled looked like the marks on the mice's necks. It was at that moment when the answer hit him like a bolt of lightning! "These occurrences there aren't caused by a disease. Someone or… SOMETHING is taking blood out of these mice!" Fievel said to himself, "I guess whatever-it-is out there is some type of…..bloodsucker!"

That newfound knowledge made Fievel cringe at the thought of something that is lurking around feeding on the blood of mice. However, those new facts led him to recall a rumor that had been going around now for weeks. He heard the mice that were attacked by this "bloodsucker" were last seen with a mouse woman that was like no other mouse ever seen anywhere. The mouse woman was claimed to only be seen at night. Also, Fievel heard that the mouse woman would take her assorts to an area underneath an abandoned saloon to where it was claimed to be her home. The saloon was said to be near by the old sheriff's office. Fievel knew that's where his old friend, Wyle Burp, use to work at. Knowing this, Fievel realized that the saloon was the former hideout of the Cactus Cat Gang before they were ran out of town. The answer then came to him; he knew exactly where he would find the culprit to those attacks. So, with all the information had, he had waited until the tomorrow evening to set out to find this "bloodsucker".