The Amazing Spider-Man 3: Part 1:

Peter Parker has definitely changed since the day after Thanksgiving, his eyes appear as though he is on some kind of drugs and his skin is quite pale. He also feels and acts differently. He is much more impulsive and constantly wants an adrenaline rush. It has definitely affected what he had of a social life. His new friend, Edward Brock Jr., who is also son of his father's colleague, has grown concerned about him and Peter has resisted his offers for help, and his old friend, Harry Osborn, has also grown apart from him, even more so than before. The truth is Peter doesn't even know what's going on. He hasn't been doing any drugs and he hasn't noticed anything else different about the world around him except some things about his Spider-Man suit. (In the movie the way I see it, Eddie confronts Peter about his alleged problem in the scene I will describe now, Eddie stands outside their dorm room as Peter is returning from his science class. "Peter," he says, "whatever is going on, I am ready to help you. You don't need to go through it alone."
"What are you talking about?" Peter asks, "I'm, fine. There's nothing wrong with me. At least not that I know of. Nothing else has changed in my life." Eddie leaves for class and Peter enters the room.
I lied, Peter thought, something did change, but it's nothing major, and if I told him about it I'd blow my cover. And the following flashback would follow) The day after Thanksgiving, he fought against a vampire and his accomplice of electricity and a mysterious substance got on his costume, turning it jet black. In addition his suit showed the ability to change to appear as normal clothes. He also found that even without his web shooters loaded (or on for that matter), the suit could generate webs tougher than the normal biocable he fired from his web shooters. But those couldn't have anything to do with it, he thought. Later, he tried Skype-calling Gwen, but she didn't answer. He didn't think to check her status,
"Working, Do not disturb."

At the OsCorp chemical lab, the chemists were working as fast as they could to replicate Dr. Reinstein's supersoldier formula from WWII. They added the final ingredient, phenethylamine (Or so they thought), and the serum turned green. "Odd." said Dr. Mendell Stromm, head OsCorp chemist,
"It says here it should be blue."
"Well, Dr. Stromm, I guess we should hope for the best and give it to Dr. Osborn."