Alterations
Sasuke had always been a rather confused individual, not that he ever showed it.
But when he was younger his mother had greatly enjoyed dressing both him and Itachi up in little girl's clothing, Lolita dresses to be precise, but the fact was the same. Because of this influence on his early years when he was still figuring out his gender identity, Uchiha Sasuke wasn't really sure if he shouldn't have been a girl, if he wasn't really a girl on the inside.
He was perfectly aware that he was a boy physically, and he had gotten around this when he was younger by wearing unisex clothing in colors acceptable for both genders. When he turned down the advanced of his hordes of admirers it wasn't really because he was completely uninterested, it was just that he didn't know which gender he should accept advances from.
So when the confused young Uchiha found out the real capabilities of the cursed seal he was slightly overwhelmed. The seal had the ability to completely alter his body's cellular structure.
After he had mastered the cursed seal Sasuke went into his room one evening and made, what he considered to be necessary alterations. Standing in front of the mirror before she went to bed that night Sasuke truly smiled, for the first time in a long time she felt comfortable in her own skin.
The next morning She got up and put on her usual uniform, which she had also altered for this occasion, the guard-skirt coming up to just below her breasts and the top fitting more snugly. Sasuke tied up her now long, but still unruly hair, put Kusanagi in its place and went on with her daily routine.
The alterations were worth it, she decided, and she carried on with her life.
The end
A rather bizarre scenario that popped into my head. Inspired by 'Side Effects May Occur' by TwinEnigma.
Now hopefully the crack-fairy will leave me alone.
Cake-chan