A/N: Ok this is my first story! In a nutshell, everyone finds out that George and Izzie slept together! And she finds herself alone! But then she finds that she is seriously ill she doesn't know what to do or how to cope. So what happens?

Set at the start of the forth season! Not sure about coupling yet!

Disclaimer: I do not own Grey's Anatomy. If I did I would not be writing this!

Derek knocked on the door. He couldn't believe what he'd just heard.

Addison opened the door. "Derek? What are you doing here?"

"I heard you were leaving…"

Addison looked at him. "Come in…"

Derek looked around her empty room. Her bags were packed and were lying on the bed. "You're really going? Why? It's nothing to do with… me… is it?"

Addison laughed. "Don't flatter yourself. I'm going back to New York. There's nothing left for me here. I need a change. I… I've done my bit here." She nodded and smiled slightly. "I heard you got chief. Well done. I knew it would happen for you."

Derek sighed. "Yeah, I turned it down. I don't w- … I don't need it. Anyway I just wanted to say... Goodbye. God it sounds so weird. You're really going?"

Addison nodded. "I'm really going. It's about time. I was only suppose to stay the week."

Derek grinned, "But you stayed to torture me."

"I stayed to torture you," she agreed. They both smiled at each other for a second.

"Good luck Addy, with everything. I hope you find what you're looking for!" Derek leant over and gave her a kiss on the cheek.

"Give me a call if you're ever in town…"

Derek nodded, he was about to leave the room when Addison called him.

"Derek…" she'd just remembered something that was playing on her mind. She knew asking Derek would help. "If you knew… or thought you knew that someone you knew was cheating on your friend… would you tell them?"

"What?"

"If you thought someone was cheating on your friend… would you tell them? Would you get involved?"

Derek thought for a second. "Yes. I wish someone had told me about you and Mark. And I bet you're glad someone told you about Meredith and me before you came down from New York."

Addison knew she he was right. "Thanks. Take care of yourself. "

As soon as Derek shut the door Addison picked up her mobile. As she dialed the number she felt slightly disloyal to the intern that she had always considered to have a promising career in her field. She sighed. "Sorry Izzie" she muttered to herself. . "Callie? It's Addison. I think I know something. I can't be definite but … I think you need to hear this. Yeah. It's about George and Izzie."

Izzie was sitting by the lockers with Meredith. They'd been chatting about everything from Derek to their new post as residents to the disposal of the food at Cristina's wedding. It was their first day back and everything seemed different.

"Can't believe Burke just left… Can't believe it…" Izzie pondered.

"She wasn't Cristina anymore. She was Cristina with no personality and no eyebrows," Meredith replied. "It's probably for the best."

Izzie sighed. "Love sucks."

"It does," she agreed.

Izzie thought carefully before she said anything. "I've kinda been feeling a bit ill lately. I don't know if it's just, you know, nothing but I…"

She was cut of by the door being slammed open. Callie O'Malley marched in looking nothing short of furious. "You bitch!" she screamed in Izzie's direction before seizing her by the neck and slamming her against the lockers. "You slutty, manipulative, deceiving bitch!"

"Callie!" Meredith cried, alarmed. "Callie get off her!"

But Callie wasn't listening as she slapped Izzie hard and sharp around the face.

Izzie muffled a scream as she staggered backwards. "Callie wait…"

"I knew it! I knew you would screw me over as soon as you could! I was nice to you, I was a friend to you… But you… you…"

Callie was over come with rage again and slapped Izzie again, knocking her to the ground with the force. .

"Alright, enough!" Meredith shouted but there was little she could do to break the two up. She tried her best to shield Izzie.

"I can't believe you…"

"Let me explain…" Izzie tried, desperately. "Callie…"

"No, no. Just don't," Callie shouted angrily pulling Izzie off the floor and holding Izzie firmly. "You think because you're… What were George's words? A blonde, stacked, supermodel? That you can just have whoever you like. We're married. He was mine. He is mine!" She was shaking Izzie violently as she spoke, smacking her into the lockers prompting Alex to rush over.

"What are you doing, man? Get off her!" He prized Callie of Izzie.

George then ran into the room. He had come in to give in his resignation from the programme following his failure of the intern examination.

He ran over to Izzie, startled. "Callie what are you doing?"

Callie just looked at him in disbelief. "And here you are protecting her. I'm your wife George. I can't believe you!"

George looked at Izzie. "You told her!"

"Told her what?" Meredith demanded. She looked between Callie, Izzie and George completely baffled. Callie looked mad, George looked like he was about to cry and Izzie was bleeding through her blonde locks.

"Well go on!" Callie said. She had noticed that everyone in the locker room was now staring at them. "Tell them what you done." She was actually staring at Izzie. "Tell them all what a selfish little slut you really are!"

Izzie looked away.

"Callie please!" George begged. "It was only once! I was drunk! It was a stupid mistake! It was a stupid drunken mistake! Tell her Izzie, tell her!"

It suddenly dawned on everyone in the room. "You slept with him?" Alex asked, pointedly to Izzie. He let Callie out of his grip and stared in disbelief.

"Izzie TELL HER!" George demanded desperately. "Callie I love you! I didn't tell you because I didn't want to hurt you. Callie listen to me…"

Callie shook her head and walked out.

George looked back at Izzie. "I can't believe you told her…" and with that he ran off after his wife.

Silence washed over the room, but Izzie could feel all eyes on her. Dr. Model, the intern who'd fallen in love and killed a patient, the doctor who had been put on probation was now being humiliated again.

"You slept with George?' Meredith said slowly. She gave Izzie a disappointed look and then followed George out of the door.

Alex was still staring at Izzie but she knew he was looking at her in disgust. She didn't know what to say. She didn't know what to do.

The door opened and Sloan walked in. "Karev, I need you down in OR 3." He looked over at Izzie. "Are you ok?"

"I'm fine." She muttered although she was almost in tears.

Dr. Sloan looked slightly concerned though. "Come find me later and I'll suture that cut." He took a glance back at her as he left.

Izzie sat down as everyone began to leave the locker room for rounds, sucking up, or Webbers first day speech. She didn't know how Callie had found out but she certainly hadn't told her. Tears rolled down her face as she thought about the look George gave her. She loved him or she thought she did. But he chose Callie. And now he hated her. And everyone hated her. She looked up as the door opened, wiping her tear stained face.

Cristina burst in looking excited. "I heard there was a fight! Did I miss it?"

A/N: Ok I promise I'll get to the point in the next chapter. Please review! And thanks for reading! I don't know which couple to go for? Gizzie? McStizzie? Or Lexie? I personally think this has a lot of McStizzie potential!