'Friend.' "And when I say 'friend…'"
In the dark cave of skulls there was one, shining white, gleaming, accusing, in sharp contrast with the dirty, brownish remains of lives once lived, ignorant thoughts once thought, grinning their devilish smiles upon the man polishing the bone, desperate to once again find the affection in the unseeing holes where eyes once peered inquiringly.
When he says 'friend', and the ghoulish rictus doesn't reply, it becomes all but clear, the determination. Moriarty's insanity in victory.
No warmth. No milk. No beating heart. No John.
The empty eyes declared Sherlock's destiny;
Not to be.
