When Wile E. Coyote attempts to catch the Road Runner once again, they soon find themselves out of the desert and onto a cross-country themed journey through many exotic places like a zoo, a race car track and even a big city. But when their desert homeland is threatened by a nasty rich couple who plan to have a new city built on their home turf, can Wile E. and the Road Runner make it back in time before its too late?