After destroying the Skull Heart to be free from enslaving by anoyne else, Painwheel returns home to be reunited with her parnets. Instead of welcoming her home, she was only to be shunned by her own parents. Feeling sad and depressed, Brain Drain was very disappointed and wants her to return to the lab for her failure. But Painwheel's eyes glow like the skullgirl's and went back to the lab to fight Brain Drain. Years later, Painwheel has settled her new life in a relationship with the experiement Razor in the Anti-Skullgirls Lab. The two were married and had a daughter named Danielle whom they raised to keep their lives a secret from her.
Years later, Danielle was now fifteen year old schoolgirl who goes to the same school as her mother went with her best friend Christine. They were sitting in the back of the room watching their teacher, Ms. Victoria writing a new school lesson on the board.
"Man, I'm so bored," Danielle whispered to Christine. "I wish I was back at home relaxing on my bed or even go to the beach to soak some waves."
"Come on, Dani," Christine whispered back. "School is not that bad. But I do wish the bell ring for lunch."
"Easy for you to say," Danielle snapped. "You're the smartest student in the entire school. Also, I heard rumors that there's a new Skullgirl out there."
"Skullgirl?" Christine echoed. "Who's that?"
"I don't know," Danielle replied with a shrug. "But all I know is that she's evil."
Christine's eyes widened. "Now that you mention it. Last night, I had a strange dream of myself walking to a mysterious room filled with skulls and there was a floating artifact that shaped like a skull in the middle of the room saying this it your fate."
"Hmm, I see." Danielle said, understanding her friend's dream. "Maybe its one of those destiny fate stuff. A lot of people have those."
"Do you have that?" Christine asked.
"Something like that, but it's too complicated to tell." Danielle replied. But inside, she had felt something her own destiny a lot more difficult than usual.
Before Christine could ask more, the bell rang and every student ran out of the classroom. Christine and Danielle grabbed their backpacks and headed to the cafeteria. After lunch and the rest of the boring classes, Danielle went to her locker just before her eyes glowed red and quickly puts her hands over her head. Once she finds herself inside her dark mind, she was confronted by a mysterious figure with a visible brain.
"You…will…return…to…me!" the robotic voice coming from the figure called out. "And…I…will…find…YOU!"
"Stop, no!" Danielle shouted. "LEAVE ME ALONE!"
Finally, Danielle returned to reality to see only a group of students staring at her as they think she's crazy or something's wrong. Immediately, Christine came to grab Danielle and run off out of the school. Walking home from school, Danielle became silent all the way.
"Dani, what happened back there?" Christine asked. "And please don't say nothing. Remember, we're best friends. You can tell me anything."
"Alright." Danielle sighed. "But remember you ask. Ever since I was new to the school, I started to see this strange person whose name himself Brain Drain telling me that he'll find me."
"Okay, I don't know who Brain Drain is." Christine admitted. "But why would he found you?"
"I don't know." Danielle shrugged. "But I'm sure my mom would know something about it."
"Good." Christine replied. "See you later."
As Danielle entered the Anti-Skullgirls Lab, she spotted her mother baking the chocolate cake and other fancy deserts with Razor. Danielle sneakily went upstairs to change from her school uniform into her baggy, off-white trousers and lavender tights with a small, lavender breastplate that supported with red that fastened to form a crisscross pattern on her back. Then, she felt something inside her body as if it wants to come out. Danielle turned to her mirror to see a large sharp pinwheel-like set on her spinal back and blood pumping on her skin. She puts her hands on her head again to hear that metallic voice in her head.
Your body seems to have full Skullgirl blood, my dear. As well as having two synthetic parasites in you. Obey Lab Zero. Find the Skullgirl and retrieve the Skull Heart to me unlike your failure mother. The metallic voice spoke.
Danielle's eyes glowed red and quickly ran downstairs to find her parents in the dining room preparing dinner.
"MOM! DAD!" Danielle called out in a guttural voice.
"Dani, you don't have to yell." Painwheel said.
"And what's wrong with your voice?" Razor asked.
Painwheel and Razor both turned around to see her daughter's appearance and gasped of what they saw. They tried to keep it a secret from her daughter, but she seems to notice about her body mutation. So, they know it's time to tell their daughter the truth.
"What's happening to me?" Danielle asked.
"Danielle, have you keep hearing voices on your mind?" Painwheel asked gently.
"Yes." Danielle replied. "But that voice belongs to…"
"…Brain Drain." Razor spoke with a growl.
"How do you two know his name?" Danielle asked curiously.
"Because your father and I were once controlled by him when I was your age." Painwheel responded. "When we were your age, the nurse named Valentine brought me and your father to Lab Zero to turn us into experiment projects, but we broke free of Brain Drain's control and destroy the Skull Heart." A single tear come from her eye. "When I went home to see my parents, they saw me as a monster and I left to live in the Anti-Skullgirls Lab."
"I'm sorry, guys." Danielle said. "But I'll find that Skull Heart and destroy for you both."
"I hope so." Painwheel said with a worried tone. "I heard the new Skullgirl has been born. She's at New Medrian inside the Grand Cathedral."
"Okay, but what does the Skull Heart do?" Danielle asked in confusion. "And who's Valentine that you were telling me about?"
"If your heart is pure, then you'll get a wish without any trouble." Razor explained. "But if your heart is impure, then you'll transform into a Skullgirl."
"And Valentine was the only survivor of the Last Hope, a group of special Anti-Skullgirl Lab operatives." Painwheel explained. "After her new life occurred, she has a daughter named Laura, who is also a nurse." She showed a picture of Valentine's daughter Laura smiling next to Painwheel. "She is following the same motives like your mom, but she's less selfish as Valentine."
"Okay, I've got it." Danielle said with a nod.
"Danielle, be safe." Painwheel reminded, hugging her.
Danielle gave her mother a tight hug. "I will."
Then, she left the room.
