This started as a prompt on Tumblr, so thankyou. This is also my first multi-chapter fanfiction so please let me know what you think.
I'll do a little explaining...
As it's an AU, Grant Ward isn't a major douche. Load of bromances occur, but it's a Skimmons fic so... The rating may change because i'm indecisive.
All right to Marvel and all that. I reference the show, and steal quotes but they don't belong to me, i just put them in the wrong context;)
btw, i'm sorry..

Chapter 1: Project GH-325

It wasn't that it was a stupid idea, as Grant said, but it wasn't extremely clever. The medical study was for the effect of something or other on a thing in your body or.. Ok, she couldn't quite remember but it was different and it didn't sound exactly dangerous, but that was what the testing was for. Skye and Trip were sat in Trip's apartment which he shared with fellow bachelor, Grant, but honestly the way they acted, you wouldn't believe the guys were straight, let alone single.
"Skye when's that medical thing you've signed up for?" Trip asked with a mock-caring tone.
"Why do you care?" Skye snapped back.
"Jesus, why so defensive?"
"I'm just sick of yours and Grant's jokes about it!"
"Ok, ok, we'll stop."
"Stop what?" Grant inquired as he entered his room with a knowing smirk on his face.
"The jokes."
"How dare you! We aren't joking about something serious as your funeral!" And a pillow met his face before he could even continue what he was saying.
Skye had known Grant Ward her whole life, or there abouts. Meeting in the foster care system, there as close as siblings and somehow along the way they met Antoine Triplett and became a rag-tag team of slackers who were known for causing trouble for 'the greater good' and for some fun of their own. But despite the trio's history, they never seemed to last longer that 5 minutes with out a fight, physical or otherwise.
"You know the-"
"Only types of people that volunteer for these things are stupid teenagers and old people, yeah, you've told be before but i'm neither and here I am."
"Give it a day or two and you could a ghost!" mocked Trip.
"Enough, already! Fucking hell!"
"Okay okay, just don't blame me when you end up in a body bag," Grant joked and Skye shot him the finger.
"And it's the day after tomorrow by the way," she mumbled.

She would have never in a million years imagined Fitz to be against her in all of this.
"There is nothing involved in this that you should be scared about, no dead-"
"For the last time, i'm not scared there is just no need-"
"Need to have dead thing were you eat, I know, I'm sorry but I really don't know what you're so worried about."
FitzSimmons, a paring like no other. When they met at University in New York, they were both extremely young and scared and... stubborn. Until a forced joint project which glued them together, both emotionally and literally(it was a long story) and made them realize they were better together than apart.
"I'm just freaked about you are testing this new drug on actual people when 3 weeks ago you didn't even think it was safe to be in the same room as some of the content!"
"Fair enough but i have been wrong before and I was wrong about this! I simply over reacted!"
"Let's hope so for all those poor people who volunteered for this thing."
"Oh Leo, don't be so dramatic!"
"I'm not being dramatic, I'm being perfectly bloody reasonable!"
"Fine, fine!" Simmons breathed, giving in to the repetitive argument, "I'm going to get some lunch would you like some?"
"Yeah ok, just make sure we steer clear from the site, i hate the biology department."
"Alright you big baby," Jemma said in a mocking tone. "It doesn't start until tomorrow anyway."

The building was large and rather intimidating, much larger than Skye had imagined with some rather scary people walking towards it. Maybe this wasn't such a good idea, Skye thought. Oh don't be such a wuss, you can't back out know, you'd never hear the last of it. As she neared the building, she saw a group of people who looked like they knew what they were doing and tagged along behind them at a safe distance and was ushered by a few people into a large hall filled with seats. As much as she hated to admit it Ward had been right about the other volunteers. About half were over 60, just of 25% were probably students off campus from various frat parties and the rest were a mix of men that probably lived in their parents basements and people that looked like they couldn't count backwards from. What have i done.

Jemma was probably the youngest doctor on the program but she was used to that. about 500 doctors had applied to help with the research but many were turned down due to the lack of volunteers willing to partake so only 176 doctors were taken on board. One per patient. What if i get put with someone i cant deal with. Oh lord...

"Ladies and Gentlemen, welcome to Project GH-325. Our aim is to help boost the bodies immune system by increasing the bodies ability to produce antibodies and regenerate body tissues. In the following months, we should be able to attain enough information for the drug to be able to go public. For the next week you shall make a note of everything you do. When you eat, sleep, run, walk, work you make note of it, starting the second you leave this room. This isn't a game, might I say, so if you signed up for this as some sort of prank please leave now."

About 12 boys then got up and left and Skye couldn't help but laugh.

"Right, now, on your seat is a number, each number pairs you up with your doctor, this week you will report to your doctor 3 times, no more, no less, but times can be made to fir both of your schedules. All of you will report back here this time next week for another briefing on the project. Now, time to meet your doctors, and doctors vice-verse. Good luck everyone, i'll see you in a week."

And the room clapped and the man, Dr Matthew Heswick, stepped down and left. Jemma looked down at the volunteers and worked out which who was hers.

Skye turned around in her seat. #084, ok, so which lucky doctor get the pleasure of me as company for the next few months, and she looked up and saw a very cute looking doctor smiling at her and making her way through the crowd towards her. Maybe this wasn't a bad idea after all...