As the reach of humanity increased, so did the reach of the Nephilim. The Clave found runes that could send a shadow hunter far beyond Earth. Starfleet heard rumours of humans hopping across the stars, but they were dismissed as wistful thinking.
The Institutes found more planets than Starfleet ever did, and operated the same as on Earth.
A pair of Parabatai were sent to a Clave discovered planet to kill a demon that was threatening to destroy the natural world there. Alexa (Lexi) Whisperkeep and Kian Nightsong certainly didn't expect a Starfleet crew to show up on their hunt.