It had been months since Miss Spider had come to live in Aperture Science and she was happy, but that happiness would end soon, Cave Johnson was dying from moon rock poisoning which he was trying to ground up to make a new gel, he called Miss Spider to his office and said" As you know…I'm dying*Cough* and I haven't got much time left…so I want you to take my place…*Cough*and since you're part robot…*Cough* I was thinking of making you the head A.I…What do you think?*cough*" Miss Spider thought about it for a while, and then decided she would fulfill his dying wish into becoming the Artificial Intelligence.
So later, the scientists upgraded Miss Spider's body and attached her to a circular platform on the roof and changed her name to SpiDOS, Miss Spider liked the changes a bit, but she started to miss her old friends, especially James and Centipede, but she thought they'd be frightened to see her like this.
Meanwhile, James and the others were trying to look for Miss Spider, Grasshopper sighed and said" It's hopeless, we'll never find Miss Spider." But Centipede said" We can't give up! We gotta find her!" suddenly James remembered something" Hey remember Cave Johnson? He said something about a place called Aperture Science! Maybe she's there!" the others agreed but Centipede rushed them and said" What're we waiting for? Let's go!" so then they went to go look for Aperture Science.