The whole premise of TBBT is what happened to Sheldon, Leonard and their nerdy friends when Penny moved in across the hall. What if Penny didn't move in? Everything belongs to Lorre, Prady and friends.

Sheldon and Amy eat at the Cheesecake Factory

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Sheldon met Amy outside the Cheesecake Factory

"Good evening Dr. Fowler, right on time, I like that."

"Good evening Dr. Cooper. A second date, an unprecedented event."

"I must admit I have never eaten here before, I don't often eat out these days. However, I have heard good things about the place and it is close to Caltech."

"Let us go in and find out if what you have heard is true."

"Ladies first."

"Good evening, my name is Penny. Welcome to the Cheesecake Factory..."

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One hour later Sheldon and Amy entered the auditorium at Caltech

"Professor Dumbass"

"Well hello Leslie and Barry"

"Hewwo Coopah and who is this young lady?"

"Leslie and Barry, this is Dr. Amy Farrah Fowler from the Caltech neurobiology department."

"Dr. Fowler, these are my friends from the Caltech physics department. Professor Leslie Winkle and her husband Dr. Barry Kripke. Leslie is head of the physics department."

"Pleased to meet the two of you. I must have seen you around at Caltech, you seem vaguely familiar."

"It is good to see Sheldon with a new friend. Would the two of you like to come to our house for dinner a week on Saturday?..."

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After the lecture

"Thank you for the invitation Dr. Cooper, that was an interesting lecture by Dr. Tyson. He managed to answer your questions."

"Yes he did. I suppose it's an occupational hazard when you give a popular science lecture that real scientists like us can turn up and point out the errors and simplifications. I suspect he has had people like us in the audience before."

"A question for you Dr. Cooper, why did Professor Winkle call you Dumbass?"

"Ah, that's our own private joke. There was a time, especially when she was married to my old roommate Leonard, that we weren't as good friends as we are now. We used to call each other all sorts of nasty things. When they got divorced and Leonard moved back to Princeton we gradually became better friends. Now we have a friendly professional relationship. Leslie and Barry sometimes invite me to their home for dinner, although Leslie keeps trying to fix me up with someone. After Leslie's latest attempt to fix me up I realised how small my circle of friends has become these days. It is mostly people at Caltech and I don't see see them that often. Provided I see the head of department, Leslie, once a month to discuss my research Caltech let me work from home without distractions. I only come in to Caltech 2 or 3 times a month. So I went to the PhD dating service to see if I could find some more friends of my own to stop Leslie's efforts at matchmaking."

"And here we are Dr. Cooper."

"Yes here we are Dr. Fowler. I must admit after our 2 minute blind date I was thinking about giving up this blind date lark. I think you will agree that this second date has been a bit more enjoyable."

"Do you intend to go to dinner with your friends a week on Saturday?"

"Well that depends Dr. Fowler, would you like to come with me?..."