During the frist ep.

Sam and Dean are driving in the Impala.

" So what do you think of Jess."

" She's blond... you do me proud, Sammy."

" so any woman in your life."

" Always, but tell me about Jess."

"What do you want to know?"

"Are they real."

"Dean! Really?"

" hey a brother's got to know."

"... well no they are not."

" WHAT THE FUCK!! Really, dude? You snagged a girl with a boob job.. hot! Do they feel lumpy?"

" Dean, shut up."

" aww come on, where's the harm."

"...."

" Ahh the smurfs do good work.