johannvanguard: It would be cool if some of the other girls could turn into some sort of monster hybrids because of Doc Ock's experiments. Aside from the villains from Canterlot City (Dazzlings and Cinch) and Spidey's universe (Doc Ock, Hydro Man, Shocker, Mysterio), it would be nice if Sunset's She-Demon and Midnight Sparkle could reappear. It could be because of a magic/science experiment of Doc Ock that could separate the She-Demon and Midnight Sparkle from Sunset and Twilight (Sci-Twi). That way Spidey, Sunset and Twilight could fight them as their enemies. Plus Doc Ock could create his own Sinister Six using some of the villains from Canterlot City, Sunset's She-Demon, and Midnight Sparkle.
johannvanguard: It would be cool if Peter could experiment with the girls' magic powers. Then something could go wrong that could create a magic monster or turns Peter into a magic spider monster. The girls then have to work together to stop Peter.
Answer: You're right, both those ideas are really cool. I'll think about it when I start my reboot. Because I want to finish my original cut first, in case you don't like the reboot.