In the Loud household, Lisa was in her room/lab, working on something. Lily was watching from her crib. Lana came in with her pet lizard, Izzy.
"Hey, Lisa!" Lana called out.
Lisa was used to being disturbed.
"What is it, Lana?" She asked.
"I was wondering if you could look after Izzy while I'm away." She requested.
"Why would I want to look after your pet? Can't the carry out the task?" Lisa asked.
"Lori and Lincoln are out on double-dates with Bobby and Ronnie, Leni's at fashion show, Luna's at a concert, Luan, comedy convention, Lynn's got soccer practice, Lucy's busy writing her poems and Lola's at her latest pageant." Lana explained.
Lisa sighed in defeat.
"Alright. I'll care for her." She sighed.
Lana smiled as she put her lizard in a tank. She stretched her arm holding the tank over to the table, where she put it. Beside it, she put in a container full of crickets.
"Great. Now, keep on eye on her and remember to feed her twice. Got it?" Lana asked.
"Affirmative." Lisa replied.
Lana nodded before leaving, leaving Lisa alone and allowing her to go back to work. All of a sudden, one of the beakers exploded, some of the liquid flew into Izzy's tank hitting her.
"Okay, that's another fail." She said getting back up from the floor. "Fortunately, being cyborg means I'm extremely resilient. I think I'll take a break for a bit."
She walked out of the room and downstairs. With Izzy, something bad was about to happen.
()()()()
In the kitchen, Lisa was getting something from the fridge. Just then, Lily walked up to her and tugged on her sweater.
"What is it, Lily?" She asked.
The infant pointed upstairs with a worried look, meaning something was wrong. They ran upstairs, and saw a huge hole in the wall. Lisa's jaw dropped. The siblings came in and saw the carnage.
"What happened here?" Lucy asked.
"Yeah and we wanna hear the 'hole' story!" Luan joked.
"And where did Izzy go?" Lana added.
Lily tapped Lori's leg. She and the others turned around. A projector popped out of Lily's head and started to play back the incident on the wall. Everyone glared at Lisa.
"It was an accident, okay!?" She yelled.
"Well, all that aside. Let's just track down that lizard and try to find out how to turn her back." Lori said.
Everyone changed into their secret agent disguises. They activated their helicopter blades, rocket engines or rocket skates and left through the hole
()()()()
Down town, a mutated Izzy was wrecking the place. The cyborgs arrived. She saw them.
"Izzy! It's me! Lana!" Agent Mechanical whispered as she flew up to her.
"Lana, I don't think you should be doing that." Agent Electrical warned.
"Don't be worry! She'll recognize her owner." She scoffed.
Suddenly, the lizard shot out her tongue and caught her.
"Okay, worry." Lana said blankly.
She screamed as she was about to be devoured. The others grabbed hold of her and started to pull, making this a bit of a tug-of-war. Eventually, they won and were able to pull Lana free, but this caused them to slam onto the ground.
"Ew! I'm covered in spit!" Inspector Loose Screws whined.
"You and me both, sister." Agent Electrical butted in.
Izzy let out a loud roar and charged. The cyborgs readied their weapons and charged. They fired their machine guns at the lizard. But, due to it's thick skin, it hardly felt a thing.
"I thought that was worth a shot." Agent Processor joked.
"Too soon, sis!" Agent Amplifier groaned.
The beast then spun around and whacked them into a building like golf balls.
"Ouch." Agent Hardware groaned.
Izzy whacked them again and this time, sent them flying back to the house.
()()()()
At the house, the kids crashed through the wall and into the living room.
"Everyone okay? Inspector Cellular and Agent Robotics asked.
"We're fine." Leni said.
"Lisa, do you think you can make something that can cure Izzy?" Lana asked.
"Of course." Inspector Software said.
"Well, hurry!" Lincoln exclaimed as a calculator extended from his hat. "At this rate, the town will be rubble in about 45 minutes!"
She nodded and went to her room. the others looked at Lincoln.
"What? I have the some IQ as Lisa now." He reminded them.
A few minutes later.
"Alright, I've got the cure for it. Now, it's going to take more than one dose in order to be effective so at least two of you have to deliver it." She explained as he handed a syringe before getting one for herself.
()()()()
Back down town, Izzy still continued her rampage. The cyborgs arrived. She rored and charged. The lizard tried to step in them, but they were able to dodge. It tried a tail swing, but they dodged that as well. Luna and Luan tried delivering the cure, but they were swatted away.
"We're okay!" They called.
Lucy appeared next to Izzy, scaring her. In self-defense, she was kicked into a wall.
"Ouch." She groaned.
"Come on! It's 8 against one!" Lori pointed out.
Just then, Lisa and Lily were kicked away.
"Make that 6." Lincoln noted before he and Lori were swatted.
Leni pounced on the mutant, wildly wailing. She tried to stab in her syringes, but she was bucked off and landed face first.
"This one's on you two!" Leni called.
The twins looked at each other.
"You ready to ends this?" Lola asked.
"You know it." Lana replied.
Izzy charged one more time at them, but they quickly got out of the way. Lassos popped out of their hats. They spun the nooses around before throwing them and catching the lizard around the neck. They retracted the ropes and were pulled onto her back. They were having a much better time riding her than Leni. Izzy tried tossing them off but they held a firm grip and seemed to be having a blast as if this was a rodeo.
"YEEEE-HAAAAW! Ride 'em cowgirl!" They wailed, waving their hats around.
They bit down onto the covers of their syringes, pulled them off, spat them out and they simultaneously injected the liquid through the lizard's neck, which was the weak spot. Izzy started to shrink and was soon back to normal.
"Izzy! You're back, girl!" She cheered, cuddling her pet lizard.
"That was incredible!" Lori exclaimed as she and the others ran up to the twins.
The crowd cheered as their town was saved. After signing a few autographs, they left.
()()()()
At the house, they walked in impressed by the twins' fighting.
"That was pretty sick, you two." Luna commented.
"Thanks." They replied.
Just then, the heard growling. They turned to see Charles, Geo, Walt and Cliff have also mutated.
"Here we go again." They muttered.
The pets roared and charged. The siblings readied their weapons, let out battle cries and charged.