An fifteen year old Kitty was once an average schoolgirl named Lisa who goes to school with her best friends Filia, Coral, and Maria. They all hang out each other's houses, gossiping on their crushes, and having sleepovers. When they each heard about the new Skullgirl, it changes their lives forever. Later on, she was kidnapped by Aqua and took them to Lab Zero. There she was implanted with synthetic wolf parasites and infuse with the experimental Skullgirl blood, which had transforming her into the were wolf monster. In order to strain her violet and unstable behavior, Brain Drain would have to mentally control her which became her new name: Kitty.
The next day, Lisa was in the Anti-Skullgirls Lab's secretive Lab Zero, which was lead by a powerful psychic director named Brain Drain and their two assistants Valentine and Aqua with her best friend Carol. She could remember herself as the only daughter with three older brothers, but those memories started to fade once she was now laying on the table feeling pain of the undergoing experiment.
"Soul contamination stabilized." Aqua reported.
Lisa was feeling several shots on her body, implanting an synthetic parasites in her and then starting to feel another synthetic parasite implanting on her fingers. She could hear Aqua explaining that the two synthetic parasites inside of her was called Lycan Drive and Jiang Unguis.
"Begin implanting the control mechanism." Brain Drain reported.
Lisa could painfully feel strange blood flowing through her body as she was unable to move herself from the table and closed her eyes as if her life was going to end.
"Her bodies seems to have fully assimilated the Skullgirl's blood, doctor." Aqua stated. "Implantation complete. No signs of rejection."
"Good. Establishing control now." Brain Drain nodded. He turned to face Lisa as he was focusing on his psychic powers. "Obey Lab Zero. Find the Skullgirl and destroy her. Retrieve the Skull Heart and return it to Lab Zero. You are now Kitty."
At his command, Kitty's eyes were opening in an boiling red color and went out to fulfill her mission on capturing the Skull Heart.