Natsume and Ruka are alice-users from the Alice World sent by Persona to the Human World for one mission: to kill the girl with the dazzling hazel eyes and childish pigtails, Mikan Sakura. But Natsume and Ruka start to fall in love for the girl they are supposed to kill! How will Persona react? Will Natsume's and Ruka's friendship end from the rivalry for the human girl?

Natsume and Mikan get into a fight and Mikan walks away, feeling sad and angry at Natsume. But something awful happens and Mikan gets hurt. When she wakes up... she can't remember Natsume! The doctors think that Mikan's angst from the fight is unconsciously causing her mind to nullify and block out all her memories with Natsume. What will Natsume do?

Natsume and Mikan have been best friends since they were seven years old, because Mikan's parents have always been a bit ignorant to Mikan's wants and needs. Now when Mikan needs Natsume more than ever, she can't have him because of a very blonde something standing in the way.