After accepting that she would never awaken and failing in his quest to find Amata's killer, Lloyd Freeman left the Capital Alliance, seeking redemption in the liberation of the slaves of the Pitt. But in the wake of his exile, none could predict her recovery. Separated from Lloyd, Amata leaves herself to find and kill Burke, journeying to the forgotten marshland of Point Lookout.

Lloyd Freeman is joined by Amata Almodovar as they leave the safety of the halls of Vault 101 in search of his missing father, stepping into the broken world above. Along their grim path, they encounter harsh adversity and new enemies every step of the way, forge new alliances and meet new friends, and through their actions, they come to change the Capital Wasteland forever.