For as long as Izaya can remember, he has been able to see people's deepest, darkest secrets. It comes in the form of a simple sentence written above their head, including Izaya's himself. When Izaya decides to head to Ikebukuro, he is greeted with the cause of the bad feeling in his stomach. "Shizuo Heiwajima wants to die."

In the city of Valitettava, a virus outbreak occurs out of the blue, devastating the place within only hours. Mutants with excessively extra limbs, a rogue lab assistant, and new and familiar faces are what this incident have in store for Leon S. Kennedy. On top of that, he's getting a strange feeling of déjà vu. (Takes place in 2012, after the events of Damnation) (Updates Sun.)