It's 2014. Years after the series ended. The twins are now 29 and running their own defense contracting company in Porkbelly, Florida, while Johnny at age 25 is moving up the ranks at the SSGA. When an old foe gives in to his old insane tendencies, he becomes a major threat to local populace and does the unthinkable forcing Susan and Mary to get involved to take him down.

It's October 2018, Dexter is now 28 and is the head of DexLabs. Dexter was invited to a business affiliates dinner party hosted at their personal mansion. With everyone else busy and Dexter not wanting to be alone in case things get boring, he asks Susan Test, now 33, if she could accompany him. It becomes a fight for their lives when waves of undead are unleashed in the mansion.