In the years following the outbreak of the cordyceps epidemic, Joel and Tommy's struggle for survival triggers the slow deterioration of their relationship. Follow them through the years as they flee their hometown, drift through quarantine zones, learn brutality and survival on the open road, and eventually find themselves in a city called Boston.

Following the traumatic events of the winter chapter, Ellie and Joel begin to truly rationalize their relationship as they help each other deal with their demons on the way to Salt Lake City. Starts immediately after the restaurant scene where Ellie kills David.