Sam leaves to take care of a quick and easy hunt on his own—and goes missing. Frantic, Dean searches for days and finds his little brother in a hospital, and in a coma. Now it's a race against time to find out what did this to Sammy, and figure out how to save him before it's too late. Hurt!Comatose!Sam, Protective!BigBrother!Dean, and Bobby too.

What if Mary had listened to Dean's warning to stay in bed? Young Dean wakes up to the sound of his brother crying. He thinks his Mom will take care of Sammy, but he doesn't hear her footsteps. So he goes into Sam's nursery instead. Azazel remembers that Dean is supposed to be the one who kills him in the future and he decides to kill him first...