James' life becomes a living nightmare when Giovanni decides to test an experimental drug on agents he feels are weak. Jessie learns to embrace love, while Mondo learns protecting the innocence of others can sometimes demand sacrificing your own instead.

On the eve of a major surgery, Bailey and her patient - Harold O'Malley - share a quiet conversation.

Her world was falling down around her, and all she could think about was that her wrists were hurting.