Sholt Giro is a shy rich kid who's an up-and-coming Charisma Duelist. Fullcross is a VRAINS avatar who violently injures people in his own sense of justice to purge VRAINS. Both of them are making their own way in the virtual online world filled with killers, fakers and a lot of people after them. Where will their paths take them? And when will they cross? Into the VRAINS!