Six years after Sara leaves the lab and Las Vegas, Grissom retires and moves to Boston. There, he finds a nice compromise to the life he's always loved, and his old friend, Dan. Little did he know that he and Dan have a mutual acquaintance.

When Ecklie chooses Grissom's team to go to a convention in London, the nightshift CSIs are obviously excited. Then their plane crashes into the Atlantic. Now the CSIs are stranded on a desert island where their only way home is to survive...