Arizona Robbins, college sophomore and local lothario, hooks up with a beautiful stranger in a local bar. Three weeks later, she finds out that not only is the woman attending the same university as her but also that she has won the affections of Arizona's older brother Tim.

When Tim brings Callie, his best friend, home with him to meet his sister sparks fly, but Callie has to go overseas for a year. Can they make it though family, friends, time, and kidnapping? (Calzona, Tim/Teddy, Teddison)