With Delta's escape, Rapture has become a place where the only life that matters is your own. Someone will now take the seat as leader of Rapture only this time he has created something that is more vicious to his enemies than a Big Sister, yet something is different about these new protectors. Rapture introduced the Big Brother.

Remy, a seventeen year old girl, must leave her twelve year old brother, Max, to get medication for her sick grandmother during The Annual Purge, but when she is coming back from another successful gathering, she saves someone who will either have changed her life for the better or for the worse.