Tweek Tweak has had mental issues since he was kid. Put on medicine at a young age at a young age left him living like a zombie. The memory loss that came with his pills caused him to fail his science test and his teacher assigned Craig Tucker to tutor him, but Craig helps him with so much / Warning Suicidal thoughts, and drug use.

Kyle Broflovski was diagnosed with cancer. Stan decided instead of wallowing in sorrow, they should make the best of a bad situation, prompting the two boys plus an eager Kenny McCormick to pursue the road trip of a lifetime. But will Kyle's increasingly risky behaviour put a toll on his ailing health?