True Van Helsing has renounced her family name, unaware that a Devil's Gate has been opened releasing a dark tide the likes of which the world has never known. Good and evil are on the brink of war, and a demon out for Van Helsing blood is on the hunt. The only chance True has to survive is to put her trust in the Winchesters, two hunters who have their own problems to deal with.

She has always carried heavy secrets, afraid of what kind of danger she will be to those around her. When she wakes up in the middle of the woods covered in blood and no memory, she has no idea what to do, but she knows her father will be after her soon enough. Her problems multiply when not only her father is hunting her, but two mysterious men in a sleek, black car as well.