Main Characters:
Freshmen:
Joshua Bassett as Jack Simpson: Type A personality, he involves himself in as many activities as he can but his true passion is for acting.
Sadie Stanley as Isabella Jones: an intelligent but stubborn girl who has issues being with loneliness.
Dara Renee as Melika "Mel" Carter: a preppy musician who longs for the love she writes about.
Sophomores:
Mina El Hamman as Lulu Abbas: a bright and bubbly girl who is questioning what it means to be Muslim.
Dylan Sprayberry as Julian Davis: Degrassi's star football player who finds himself caught between two lovers.
Kevin Quinn as Eric Palmer: a nerdy introvert who spends most of his time online gaming.
Dove Cameron as Ashli Channing: a pregnant teenager whose starting fresh at Degrassi.
Adults:
Aislinn Paul as Clare Goldsworthy: a mother of triplets who moves back to her hometown for work.
Shane Kippel as Spinner Mason: The Dot's owner and Emma's husband.
Adamo Ruggiero as Marco Del Rossi: Degrassi's history teacher.
Stacey Farber as Ellie Nash-Scott: a journalist who is trying to start a family with her husband.
Miriam McDonald as Emma Nelson: a human rights activist and Spinner's wife.
Recurring:
Students:
Rowan Blanchard as Luna Bledsoe: a nerdy teen and Eric's friend who is a part of the gamer's club. She secretly has a crush on Eric. (Grade 10)
Skai Jackson as Margo O'Neal: Quinn's younger sister and co-captain of the power cheer team, she has a very matter of fact personality. (Grade 11)
Spencer List as Tyler Roxanne: someone from Ashli's past. (Grade 11)
Sofia Wylie as Hanna Armstrong: director and cartographer for Degrassi's drama department, she's very shy until you get to know her. (Grade 11)
Roshon Fegan as Kyle Armstrong: Hanna's twin brother and homophobic and sexiest football player. (Grade 11)
Josie Totah as Juliet Charming: The queen bee of Degrassi, she's has a recurring spot in West Drive. (Grade 11)
Riele Downs as Quinn O'Neal: Degrassi's charismatic cheer captain who takes power cheer very seriously. (Grade 12)
Adults:
Moira Kelly as Mrs. Channing: Ashli's loving mom, she's a stay at home mother.
Matthew Morrison as Mr. Channing: Ashli's father, he works at a law firm.
Melissa Ponzio as Mrs. Davis: Julian's easy-going mom, she owns the winery with her husband.
Mike Faiola as Mr. Davis: Julian's easy-going father, he owns a winery with his wife.
Maysoon Zayid as Mrs. Abbas: Lulu's strict mother who follows her religion closely.
Faran Tahir as Mr. Abbas: Lulu's father who believes his religion is the right and only religion to follow.
Amanda Stepto as Christine Nelson: Emma and Jack's mom who is going down a dark path.
Nina Dobrev as Mia Jones: Isabella's detached mom and fashion icon.
Marc Minardi as Lucas Valieri: Isabella's father who has made some mistakes in his life.
Munro Chambers as Eli Goldsworthy: Clare's husband and famous screenwriter/director. He spends most of his time in New York.
James Lafferty as Gregg Scott: Ellie's husband and Spinner's business partner.
Cassie Steele as Manny Santos: an award-winning actress and Emma's best friend.
Mike Lobel as Jay Hogart: Manny's loving husband.
Michael Kinney as Darryl Armstrong: Degrassi's gym and math teacher.
Aisha Alfa as Ms. Grell: Degrassi's guidance counselor.
Ashley Comeau as Ms. Badger: Degrassi's science teacher.
Michael Brown as Mr. Mitchell: Degrassi's English teacher, drama club leader, and creative writing head.
Janick Hebert as Madame Jean-Aux: Degrassi's French and Art teacher.
Melissa DiMarco as Daphne Hatzilakos: Degrassi's principle.
Stephen Colletti as Jonathon Ackles: West Drive's casting director, executive produce and writer.
Guest Stars:
Sarah Barrable-Tishauer as Liberty Van Zandt: A successful lawyer.
Jake Goldsbie as Toby Isaacs: A web site designer.
Jake Epstein as Craig Manning: A successful musician whose taking a break from music to peruse Broadway.
Daniel Clark as Sean Cameron: Emma's ex who now owns his own auto mechanic shop.
Shenae Grimes as Darcy Edwards: Clare's sister and Drew's current girlfriend.
Luke Bilyk as Drew Torres: Darcy's boyfriend.
Ruth Marshall as Helen Martin: Clare's mom and Glen's wife.
Graham Abbey as Glen Martin: Clare's stepfather and Jake's dad.
Justin Kelley as Jake Martin: Clare's stepbrother who works for his dad in a company they share.
Olivia Scriven as Maya Matlin: An award-winning singer-songwriter.