Richard and Mary Parker were very two of the best SHIELD agents Nick Fury had ever worked with. When Mary became pregnant he was sorry to see them go, but he knew it would be unfair to their child and them if he asked them to stay.
Richard decided to use his skills to help people. He started working at Oscorp, specifically in the creation of cross-species genetically altered animals. What if he could give a person the ability to regrow a limb? His work would save lives.
That is when he got the call. Nick Fury had discovered that Oscorp were going to use his research for their sinister purposes. They were going to use the genetically altered, radioactive spiders he had created to give HYDRA an army of super soldiers. HYDRA had always wanted to create an army of super soldiers, ever since Captain America. Now they were going to use his research to finally achieve their goal.
He couldn't let that happen. He killed every spider he could, destroyed every sample of venom of the spiders. He wiped all the data from the computer system. He wiped all the backup data, even the ghost drives Oscorp had worked so hard to conceal.
He left Oscorp, on his way home he called Director Fury, asking for a favor. If they were going to get away, they needed to get on a private jet and leave immediately. When he got home he grabbed the emergency bags that he and Mary had from their old SHIELD days.
They left Peter with his brother Ben and his wife May. They would be putting them in terrible danger, but it was the only way Peter would be safe. The only way he could live a normal life. The life he and Mary had sworn they would give him.
They arrived at the airport and went straight to the private jet Fury had gotten for them. It was only at 30,000 feet, halfway over the Atlantic Ocean, when they heard it. BEEP, BEEP, BEEP. They both knew immediately what it was. BOMB. He closed his eyes, and knew nothing else.