Commissioned: The Green Flu struck earth like a meteor, in its clutches billions died, and a new world emerged. Now it is the year 2156 and that which has been dreaded by humanity ever since the truth of the Green Flu has come to pass. First Contact.

First comes the infection, then the symptoms. The signs are there, the galaxy is sick of the infected humans. To prevent war, Shepard and the Normandy crew must show the galaxy that it's possible to live peacefully alongside humans, even if they do have this uncontrollable urge to mutilate. Sequel to First Infection.

Many have liken the Citadel to a massive hand: snatching various races from their homes, and clutching them together in its palm, where they learn to live peacefully, side-by-side. But now that hand is reaching for a race that will only make it recoil in disgust.

Humanity has fallen to the Green Flu, yet rose up to face the stars, watch as the Infected fight the Turians and kick their ass, make friends with the outcasts of the Council, and show the Reapers that even if they are a mistake, they are one that drags them to Hell as they once thought themselves part of.