Four Defenders. Four versions of the Doctor and companions. Four different groups of aliens have come to New York City for one sinister and evil plan. Can the Doctors and Defenders defeat the aliens and save New York once again?

Soraya Ebadi is a rehabilitation specialist, with numerous clients of varying wealth and social status, but when she is hired to help Ward Meachum get clean, her entire life changes. She is soon embroiled in a world of powered people, ancient organizations, death threats, and violence. Can Soraya and Ward survive the oncoming storm?