J'onn tries his best to get other aliens to rise against it but they decide not to get involved because it's not their problem & for some reason the Supers also lose their allies then even Superman runs from his responsibilities, decides to go to a different Earth & this causes Lois Lane to become Anti-Alien too. Once Supergirl sees this & becomes devastated she decides to take a leave of absence from the life that she's known as well as leaving National City for Midvale with Eliza. Once Eliza sees her other daughter pull up she rushes out to greet her then helps her bring her bags up to her room as well as other things to be put in the P.O.D.S. & after that they sit down to eat but before they dig in a knock on the front door causes them to pause whereupon Eliza gets it & the next thing Kara knows' her mother introduces the stranger as her boyfriend Riley Grant who decided to surprise her for dinner, After that they go on an impromptu date thus leaving the other to herself but less than 20 minutes later she decides to go to the local bar. Once there she orders a drink & posts herself at the bar where she ends up running into Eliza & Riley whereupon she & Riley go play pool while Eliza goes to see an acquaintance from work whereupon they end up leaving Riley & Kara due to an unforeseen work issue at Midvale Medical Labs. After a while, Kara tries to leave but he & a friend of his have other plans for her; they end up injecting her with Green Kryptonite where his friend, a Daxamite, rapes her then leaves her unconscious but the police get called once the bartender finds her where the police then track Riley & the Daxamite who say when they left her she'd been just fine. 2 weeks after that she finds out she's pregnant but can't remember what happened to herself then 4 weeks after that she decides she needs to leave this planet & decides to move back to her homeworld of Argo City where she ends up finding out Cat's there because the older woman's been almost assassinated a total of 6 times due to her abhorrence of Earth's alien act & when she sees Carter for the 1st time, in a long time, he rushes over to give her a bear hug but once she feels her baby kicking she rushes out of the room to her own where she can be alone with herself. Later on, she answers the knock at her door which she promptly opens which reveals her Aunt Astra who asks why didn't she just get an abortion. Kara answers that she almost did but once she heard a faint heartbeat she decided against it. The very next day she spends it with her parents then a few days later she resumes the royal duties of her House. In the middle of that day she, her family & the Grants have lunch & when Carter sees that she can't decide on dessert he decides to tell her some of his faves. She decides to try them all then once everyone finishes the Zor-Els return to their duties. When Carter hears their going to the Science Guild he asks to tag along & they say yes. Meanwhile, Cat goes to see his actual father who turns out to be Kara's alien rapist's father King Lar Gand of Daxam but a few hours later she disappears. After that, Kara returns to Earth 5 years later, once Lockwood gets ousted as POTUS, & she uses her advanced knowledge to get a job at LCORP where she & her son get the attention of a certain CEO. When Kara crashes into a fellow employee she grabs onto their waist & them on her shoulders where Kryptonite Green & ice blue eyes meet each other which causes them to get lost in each other but a few seconds later it gets broken by Kara's son & Lena's assistant Jess. Once Kara sees her son she goes to scold him but Jess intervenes stating that it'd been her fault because once she saw him she brought him to go get snacks. Kara asks him if he said thank you, to which he did, then Jess introduces the other woman to both of them but as Kieran Thorul. After that everyone goes on their way but later Lena & Kara meet as boss & employee. This happens when Kara gets summoned to the CEO's office but on her way there she gets kidnapped by a CADMUS agent where she gets turned into a Kryptonian/Daxamite vampire/werewolf known as Cyborg Superwoman. A few days later she shows up at the DEO where Agent Schott's going through a deep dive of various encrypted alien files when all of a sudden a crash from above almost crushes him but he ducks out of the way but later he reemerges from the debris.
When he sees a half-human/half cyborg he rushes to go get J'onn whereupon the Martian Manhunter engages with said cyborg where he almost loses except to be saved by Jess, daughter of deceased Slayer Nikki Wood, who used her smarts to rush to the DEO armory to get a Green K ray gun whereupon she uses on cyborg but they laugh of the sting of it so she then uses her secret weapon of Vervian/Wolfsbane which causes the cyborg to fall then Jess, J'onn, Alex & some other agents bring the hostile to a very secure cell whereupon alternate dimension (vampiric) Willow Rosenberg. A few hours they both awaken from their slumber where they form a plan to help each other out but when vamp Willow attacks Lena Cyborg Superwoman destroys said vamp but once she does that because it's her 1st kill, her werewolf transformation starts; it causes her bones to break apart & realign themselves. Once it ends more agents rush to subdue her but she starts killing them.
Jess sees that a coin fell out of her pocket so she rushes to pick it up but it starts burning her hand so she throws it at Lena who ends up saving more agents from dying because when the cyborg sees it in the young woman's hand she surrenders to the other. But when Lena finds out what this means she tells the others she can't & a few days after selling LCORP to Andrea Rojas she disappears with the new name of Elizabeth 'Beth' McGrath & at the same time Cat Grant awakens at a CADMUS facility subsidiary called the Initiative where it's revealed she'll be trained as a Slayer to kill the Maiden of Might. A few days after that Cat returns to the living where she gets in an accident with the youngest Luthor & CADMUS rekidnaps them & remodifies their minds so CADMUS' plans don't get screwed up. A few months after that Cat tries to help Cyborg Superwoman who ends up refusing & leaves National City for somewhere else with the new name of Alura Benoist. Once God sees that them meeting each other 1st instead of Kara & Cat's a good thing he reverses time where Kara still works for the youngest Luthor; after waiting 45 minutes to see the boss about the labs Kara's finally able to see each other & once they do they remember that they saw each other before but before they can complete their meeting Jess bursts through the doors saying some mysterious looking officials' there to see Lena who then realizes that they're from the A3 so she asks Kara if she's an alien to which the other says yes so Lena tells Jess to enact the Elope Effect Protocol once Kara agrees to it. She tells Jess to put the gentlemen in another room until she can get to them. After that, she gets Jess to rush the paperwork through for Lena & Kara to sign. Once that happens they go to see the gentlemen who ended up 'discovering' their 'recent relationship'. Once the meeting adjourns Lena & her walk to Noonan's for lunch then go to Kara's storage to bring her stuff to the Penthouse & once that's done they spend the rest of the day getting to know each other. A few months after that they reveal their marriage to all of the elite of Gotham, National City & Metropolis.