Ami’s been taken from her universe again! Only this time she’s all alone, or is she? Not with these three adorable heroes by her side! Can three little girls made from sugar, spice, and everything nice help our favorite senshi of ice? Read to find out!

The PowerPuff teens travel to a different town, and meet five teenage girls who are secret Sailor Scouts. Once the teens hang out with each other, The RowdyRuff adults and the children of the PowerPuffs enemies have found out about this and decide to go fight them. Can our heroes be able to fight with the help of their new friends?

Professor Utonium's friend, Miss Haruna from college is going away to visit her sister. Professor Utonium agrees to visit Japan to cover for her job. But what happens when The Negaverse steals energy from The Professor and possess him and the other teachers to drag the School to the Negaverse? It's up to both The Powerpuff girls and The Sailor Scouts to team up and save the day!