Alex knew for the past few weeks he was losing Izzie to Denny. He had known it would eventually come sooner or later. Sooner came tonight. Denny had asked him what were his chances on his condition. Dr. Karev told the truth. Patients in similar situations did not have a great chance of survival.

Four had died throughout the day, three more to go. Alex had been so sure Denny would had been one of them. He actually told Denny that Izzie did indeed like him and that she would not be the one to pull away.

Alex was wrong. Izzie did pull away only he hadn't expected that she'd pull away from him. She broke his heart in several pieces and ended their relationship.

Izzie knew her relationship with Denny was much more than just doctor/patient. She worried about him. Denny thought for sure that his days were numbered and mentioned to Izzie the location of his will.

Her relationship with Alex was merely for sex. With Denny, she actually had deep feelings for him. She told Alex that Denny was twice the man he was and told him they were through. He was not good enough for her or anyone else for that matter.

She never thought she'd fall for a patient. Izzie was the one who had initiated their kiss.

A Kiss So Hot you don't want to come up for air. No, wait a minute. That was with Alex at Joe's Bar. She'd forgotten.