Just thought of some interesting concepts let me know what you think.
What if: Eda found the 10 rings (Shang Chi)
What if: Lilith used Extremist (Iron man 3)
What if: Luz was a Daywalker (Blade)
What if: Ultron was used for the new portal
What if: Frank Castel hunted Eda (The Punisher)
What if: Belos used the infinity guantlet
What if: Mystero became a real illusionist (Spider-Man: Far from home)
What if: Loki invaded the isles instead of earth
What if: Eda worked with The Vulture (Spider-Man: Homecoming)
What if: Lilith made a deal with Dormammu (Doctor Strange)
What if: Luz was part of Weapon X (X-men)
What if: Carnage was transported to the isles (Venom: Let there be Carnage)
What if: Vee was brainwashed by HYDRA
What if: The "Hex" reached the isles (Wandavision)
What if: Eda and Lilith broke time (Loki)
What if: Camila married Eddie Brock (Venom)
What if: Eda stole vibranium (Black panther)
What if: Lilith cursed Bruce Banner (The incredible hulk)
What if: Luz ate the heart herb (Black panther)
What if: Raine was taken by the Grandmaster (Thor: Ragnarok)
That's all the ideas I have for now, don't forget to review the other chapters, it's just inevitable that the clawthorne sisters will be in tight situations.